EVALUATION OF QUALITY OF LIFE, PSYCHOLOGICAL STRESS, AND MEDICATION ADHERENCE AND THEIR CORRELATION AMONG KIDNEY TRANSPLANT WAITING-LIST PATIENTS IN A TERTIARY CARE HOSPITAL IN INDIA
Author(s)
Priyanka R. Singh, PharmD1, Siddhi Ranjeet Bhalekar2, Gaziya Samsher Sayyed3, Ketaki Shinde3.
1Student, Dr. D.Y. Patil Dnyan Prasad University's School of Pharmacy and Research, Pune, Pune, India, 2Dr. D.Y. Patil Dnyan Prasad University's School of Pharmacy and Research, Pune, Rajgurunagar, Pune, India, 3Dr. D.Y. Patil Dnyan Prasad University's School of Pharmacy and Research, Pune, Pune, India.
1Student, Dr. D.Y. Patil Dnyan Prasad University's School of Pharmacy and Research, Pune, Pune, India, 2Dr. D.Y. Patil Dnyan Prasad University's School of Pharmacy and Research, Pune, Rajgurunagar, Pune, India, 3Dr. D.Y. Patil Dnyan Prasad University's School of Pharmacy and Research, Pune, Pune, India.
OBJECTIVES: Primary Objective: 1. To assess the quality of life (QoL) among kidney transplant waiting-list patients. 2. To examine the correlations between QoL, medication adherence, and psychological stress. Secondary Objective: 1. To identify sociodemographic and clinical predictors influencing quality of life in waiting list renal transplant patients.
METHODS: A cross-sectional observational study was conducted over one year at Dr. D. Y. Patil Medical College, Pune, India, involving adult (≥18 years) kidney transplant waiting-list patients on maintenance hemodialysis. 79 participants were enrolled based on predefined criteria. Data were collected through face-to-face interviews using validated instruments like KDQOL-36, PSS-10, and MARS-10. Statistical analyses were performed using R, Jamovi, JMP, and Microsoft Excel, with ethical approval from the Institutional Ethics Committee prior to the study.
RESULTS: A total of 79 kidney transplant waiting-list patients receiving maintenance hemodialysis were studied (mean age 43.0 ± 12.2 years; 65.8% male). The mean KDQOL-36 score was 52.3 ± 18.0, and the mean Perceived Stress Scale (PSS) score was 19.4 ± 8.7, with 74.7% experiencing moderate-to-high stress. Perceived stress strongly correlated with lower quality of life (r = −0.702, p < 0.001), while medication adherence showed no significant relationship with quality of life (all p > 0.05). Multivariable regression found higher perceived stress to be the strongest predictor of poorer quality of life. Additional factors associated with lower quality of life included greater financial burden, diabetes, longer disease duration, and higher medication burden.
CONCLUSIONS: Renal transplant waiting-list patients face significant quality of life challenges due to psychological stress, disease burden, financial issues, and treatment factors. Perceived stress is a key factor negatively affecting various quality of life aspects. Regular assessments of psychological well-being, medication challenges, and socioeconomic factors, along with multidisciplinary support, could enhance quality of life and treatment outcomes for these patients.
METHODS: A cross-sectional observational study was conducted over one year at Dr. D. Y. Patil Medical College, Pune, India, involving adult (≥18 years) kidney transplant waiting-list patients on maintenance hemodialysis. 79 participants were enrolled based on predefined criteria. Data were collected through face-to-face interviews using validated instruments like KDQOL-36, PSS-10, and MARS-10. Statistical analyses were performed using R, Jamovi, JMP, and Microsoft Excel, with ethical approval from the Institutional Ethics Committee prior to the study.
RESULTS: A total of 79 kidney transplant waiting-list patients receiving maintenance hemodialysis were studied (mean age 43.0 ± 12.2 years; 65.8% male). The mean KDQOL-36 score was 52.3 ± 18.0, and the mean Perceived Stress Scale (PSS) score was 19.4 ± 8.7, with 74.7% experiencing moderate-to-high stress. Perceived stress strongly correlated with lower quality of life (r = −0.702, p < 0.001), while medication adherence showed no significant relationship with quality of life (all p > 0.05). Multivariable regression found higher perceived stress to be the strongest predictor of poorer quality of life. Additional factors associated with lower quality of life included greater financial burden, diabetes, longer disease duration, and higher medication burden.
CONCLUSIONS: Renal transplant waiting-list patients face significant quality of life challenges due to psychological stress, disease burden, financial issues, and treatment factors. Perceived stress is a key factor negatively affecting various quality of life aspects. Regular assessments of psychological well-being, medication challenges, and socioeconomic factors, along with multidisciplinary support, could enhance quality of life and treatment outcomes for these patients.
Conference/Value in Health Info
2026-11, ISPOR Europe 2026, Vienna, Austria
Value in Health, Volume 29, Issue 12S
Code
PCR206
Topic
Health Service Delivery & Process of Care, Patient-Centered Research, Study Approaches
Topic Subcategory
Patient-reported Outcomes & Quality of Life Outcomes
Disease
Systemic Disorders/Conditions (Anesthesia, Auto-Immune Disorders (n.e.c.), Hematological Disorders (non-oncologic), Pain), Urinary/Kidney Disorders