ESTIMATING A UK EQ-5D-Y-3L VALUE SET USING A STAKEHOLDER-INFORMED PROTOCOL FOR A HEALTH VALUATION STUDY
Author(s)
Oliver Rivero-Arias, MSc, DPhil1, Helen Campbell, MSc, DPhil1, Donna Rowen, BA, MSc, PhD2, David John Mott, PhD3, Koonal Shah, PhD4.
1Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, United Kingdom, 2SCHARR, University of Sheffield, Sheffield, United Kingdom, 3Office of Health Economics, London, United Kingdom, 4NICE, London, United Kingdom.
1Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, United Kingdom, 2SCHARR, University of Sheffield, Sheffield, United Kingdom, 3Office of Health Economics, London, United Kingdom, 4NICE, London, United Kingdom.
OBJECTIVES: A value set reflecting UK population preferences for the EQ-5D-Y-3L is not currently available. A stakeholder-informed protocol, developed through consultation with academics, policymakers, and other stakeholders and informed by the international EuroQol EQ-5D-Y-3L valuation protocol, was implemented for this study. We aimed to estimate a UK EQ-5D-Y-3L value set using this protocol.
METHODS: The study design included adults (≥18 years) and adolescents (11-17 years) residing in the UK. A discrete choice experiment (DCE) is being administered to both adults and adolescents to estimate the relative importance of EQ-5D-Y-3L dimensions and severity levels. To anchor latent DCE values onto the quality-adjusted life-year (QALY) scale, adults completed composite time trade-off (cTTO) tasks imagining the health state experience by a hypothetical 10-year-old child. cTTO interviews were administered remotely by trained interviewers using videoconferencing and 28 health states were valued. Descriptive analyses were conducted to summarise cTTO responses.
RESULTS: DCE data collection is ongoing. A broadly representative sample of 204 adults, stratified by age, sex and nation completed the cTTO tasks. Participants from social grades ABC1 (higher, intermediate and junior managerial, administrative, professional, supervisory and clerical occupations) were overrepresented, and 64% reported having children. Mean (standard deviation) of observed cTTO values ranged from −0.159 (0.644) for the worst health state (33333) to 0.977 (0.046) for health state 12111. Of the 28 health states valued, only health state 33333 had a mean value below zero, indicating that it was considered worse than dead.
CONCLUSIONS: cTTO data collection has been completed and will be used to anchor DCE latent-scale preferences to estimate the first UK EQ-5D-Y-3L value set. The study demonstrates the feasibility of implementing a stakeholder-informed valuation protocol designed to maximise the acceptability and relevance of the resulting value set for decision making in the UK.
METHODS: The study design included adults (≥18 years) and adolescents (11-17 years) residing in the UK. A discrete choice experiment (DCE) is being administered to both adults and adolescents to estimate the relative importance of EQ-5D-Y-3L dimensions and severity levels. To anchor latent DCE values onto the quality-adjusted life-year (QALY) scale, adults completed composite time trade-off (cTTO) tasks imagining the health state experience by a hypothetical 10-year-old child. cTTO interviews were administered remotely by trained interviewers using videoconferencing and 28 health states were valued. Descriptive analyses were conducted to summarise cTTO responses.
RESULTS: DCE data collection is ongoing. A broadly representative sample of 204 adults, stratified by age, sex and nation completed the cTTO tasks. Participants from social grades ABC1 (higher, intermediate and junior managerial, administrative, professional, supervisory and clerical occupations) were overrepresented, and 64% reported having children. Mean (standard deviation) of observed cTTO values ranged from −0.159 (0.644) for the worst health state (33333) to 0.977 (0.046) for health state 12111. Of the 28 health states valued, only health state 33333 had a mean value below zero, indicating that it was considered worse than dead.
CONCLUSIONS: cTTO data collection has been completed and will be used to anchor DCE latent-scale preferences to estimate the first UK EQ-5D-Y-3L value set. The study demonstrates the feasibility of implementing a stakeholder-informed valuation protocol designed to maximise the acceptability and relevance of the resulting value set for decision making in the UK.
Conference/Value in Health Info
2026-11, ISPOR Europe 2026, Vienna, Austria
Value in Health, Volume 29, Issue 12S
Code
EE557
Topic
Economic Evaluation, Methodological & Statistical Research, Patient-Centered Research
Disease
Pediatrics