TWELVE-MONTH ISCHEMIC STROKE RISK AFTER NON-CARDIOEMBOLIC ISCHEMIC STROKE OR TRANSIENT ISCHEMIC ATTACK: A REAL-WORLD STUDY USING A REGIONAL ELECTRONIC HEALTH RECORD DATABASE IN CHINA
Author(s)
Jing Wu, PhD1, Xin Cheng, PhD2, Kristian Tore Jørgensen, PhD3, Rong Han, MS4, Sha Li, MD4, Yigong Zhou, MPH5, Tianmou Liu, PhD5, Yuxuan Wei, MPH5.
1School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China, 2Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China, 3Bayer A/S, Copenhagen, Denmark, 4Medical Affairs, Bayer Healthcare Co. Ltd., Beijing, China, 5Real World Solutions, IQVIA Ltd., Shanghai, China.
1School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China, 2Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China, 3Bayer A/S, Copenhagen, Denmark, 4Medical Affairs, Bayer Healthcare Co. Ltd., Beijing, China, 5Real World Solutions, IQVIA Ltd., Shanghai, China.
OBJECTIVES: The study evaluated the 12-month risk of secondary ischemic stroke (IS) among patients with non-cardioembolic ischemic stroke (NCIS) or transient ischemic attack (TIA) in China.
METHODS: A retrospective cohort study was conducted using the Tianjin Healthcare and Medical Big Data Platform. Adult patients with first hospitalization for NCIS or TIA between 2016 and 2023 were analyzed in separate cohorts. Secondary IS was defined as subsequent hospitalization with a primary diagnosis of IS or IS-related death. The cumulative incidence of IS was estimated overall and stratified by sex and age. Healthcare resource utilization was assessed using length of stay (LoS) and hospitalization costs for index event and first recurrent event.
RESULTS: A total of 371,967 NCIS and 82,334 TIA patients were included. Mean age was 65.2 (standard deviation [SD] 11.4) in the NCIS group and 63.7 (SD 11.7) years in the TIA group; 60.8% and 46.7% were male, respectively; hypertension was the most common comorbidity (80.1% and 75.3%). The 12-month cumulative incidence of IS was higher in NCIS than in TIA (16.5% and 4.6%). Incidence was higher in males (NCIS: 17.7% vs. 14.7%; TIA: 6.1% vs. 3.3%) and increased with age in TIA cohort (from 3.0% [<55 years] to 5.8% [>75 years]), with a similar trend in NCIS cohort (14.4% [<55 years] to 16.3% [>75 years]). In the NCIS cohort, median LoS and hospitalization costs of index event were 11 days and 11,865 CNY, respectively. Secondary IS was associated with high healthcare burden (median LoS 12 days) and hospitalization costs (median cost of secondary IS 16,654 CNY).
CONCLUSIONS: Secondary IS occurs frequently within 12 months after NCIS or TIA in a Chinese hospital-based population, varying by age and sex, and risk remains substantial across all subgroups. The substantial burden associated with secondary events highlights the need for early, targeted, and optimized secondary prevention.
METHODS: A retrospective cohort study was conducted using the Tianjin Healthcare and Medical Big Data Platform. Adult patients with first hospitalization for NCIS or TIA between 2016 and 2023 were analyzed in separate cohorts. Secondary IS was defined as subsequent hospitalization with a primary diagnosis of IS or IS-related death. The cumulative incidence of IS was estimated overall and stratified by sex and age. Healthcare resource utilization was assessed using length of stay (LoS) and hospitalization costs for index event and first recurrent event.
RESULTS: A total of 371,967 NCIS and 82,334 TIA patients were included. Mean age was 65.2 (standard deviation [SD] 11.4) in the NCIS group and 63.7 (SD 11.7) years in the TIA group; 60.8% and 46.7% were male, respectively; hypertension was the most common comorbidity (80.1% and 75.3%). The 12-month cumulative incidence of IS was higher in NCIS than in TIA (16.5% and 4.6%). Incidence was higher in males (NCIS: 17.7% vs. 14.7%; TIA: 6.1% vs. 3.3%) and increased with age in TIA cohort (from 3.0% [<55 years] to 5.8% [>75 years]), with a similar trend in NCIS cohort (14.4% [<55 years] to 16.3% [>75 years]). In the NCIS cohort, median LoS and hospitalization costs of index event were 11 days and 11,865 CNY, respectively. Secondary IS was associated with high healthcare burden (median LoS 12 days) and hospitalization costs (median cost of secondary IS 16,654 CNY).
CONCLUSIONS: Secondary IS occurs frequently within 12 months after NCIS or TIA in a Chinese hospital-based population, varying by age and sex, and risk remains substantial across all subgroups. The substantial burden associated with secondary events highlights the need for early, targeted, and optimized secondary prevention.
Conference/Value in Health Info
2026-11, ISPOR Europe 2026, Vienna, Austria
Value in Health, Volume 29, Issue 12S
Code
EPH111
Topic
Economic Evaluation, Epidemiology & Public Health, Real World Data & Information Systems
Disease
Cardiovascular Disorders (including MI, Stroke, Circulatory)