INCREASED RATES OF EMERGENCY CARE IN PEOPLE WITH IDIOPATHIC INFLAMMATORY MYOPATHIES: A POPULATION-BASED COHORT IN ENGLAND 2002 TO 2021
Author(s)
Patrick Gordon, PhD1, Esther Yi, PharmD, MS2, Anna Barkaway, PhD3, Saqib Rana, MRPharmS (IPresc)3, Burak Sahin, MD3, Nelly Ly, PharmD, MScRes3, Maciej Czachorowski, PhD3, Carmen Tsang, PhD4, Serhan Bahit, MSc5, Charlotte L. R. Curtis, PhD5, Janine Lamb, DPhil6, Hannah Jennifer, MD(Res), MBBS MSc17, James Galloway, PhD8.
1Department of Academic Rheumatology, King’s College London, London, United Kingdom, 2Pfizer Inc, New York, NY, USA, 3Pfizer Ltd, Tadworth, United Kingdom, 4Pfizer Inc, Tadworth, United Kingdom, 5Momentum Data Ltd, St. Albans, United Kingdom, 6University of Manchester, Manchester, United Kingdom, 7Department of Rheumatology, Surrey and Sussex Healthcare NHS Trust, Redhill, United Kingdom, 8Department of Academic Rheumatology, King's College London, London, United Kingdom.
1Department of Academic Rheumatology, King’s College London, London, United Kingdom, 2Pfizer Inc, New York, NY, USA, 3Pfizer Ltd, Tadworth, United Kingdom, 4Pfizer Inc, Tadworth, United Kingdom, 5Momentum Data Ltd, St. Albans, United Kingdom, 6University of Manchester, Manchester, United Kingdom, 7Department of Rheumatology, Surrey and Sussex Healthcare NHS Trust, Redhill, United Kingdom, 8Department of Academic Rheumatology, King's College London, London, United Kingdom.
OBJECTIVES: Idiopathic inflammatory myopathies (IIMs) are a diverse group of immune mediated conditions with a high burden of complications, but research on healthcare needs are limited. We aimed to provide a detailed assessment of healthcare utilisation (HCU) of people with IIM.
METHODS: People aged ≥ 2 years actively registered in Clinical Practice Research Datalink (CPRD) Aurum between 2002 - 2021, with linkage to Hospital Episode Statistics, and Office for National Statistics death registration data were eligible. Incident IIM cases were identified by the presence of an IIM diagnosis in secondary or primary care during the study period, with date of onset defined at the earliest record of IIM diagnosis in either care setting.
IIM cases were matched up to 1:4 with controls by age, sex, ethnicity, and socioeconomic deprivation. Negative binomial models were used to derive unadjusted Incidence Rate Ratios (IRRs). Study outcomes were the number of all-cause HCU interactions in the 2 years post-diagnosis, including outpatient attendances, accident and emergency visits, hospital admissions and critical care.
RESULTS: We identified 4,097 incident cases of IIM with a median age at diagnosis of 60 years (interquartile range 44-72) and a higher proportion of females (56.4%), matched to n=16,294 controls. IIM was associated with a marked increase in HCU rates across all outcomes compared to controls: outpatient attendances (IRR 5.61, 95% Confidence Interval [CI] 5.29, 5.96), accident and emergency visits (IRR 3.46, 95% CI 3.20, 3.74), hospital admissions (IRR 8.00, 95% CI 7.42, 8.64), and critical care encounters (IRR 8.78, 95% CI 7.30, 10.56).
CONCLUSIONS: People with IIM have substantially increased healthcare utilisation across secondary care in the two years following diagnosis, highlighted by particularly high burden of emergency and critical care encounters. These findings highlight the importance of considering potentially complex healthcare needs in people recently diagnosed with IIM as part of their care programme.
METHODS: People aged ≥ 2 years actively registered in Clinical Practice Research Datalink (CPRD) Aurum between 2002 - 2021, with linkage to Hospital Episode Statistics, and Office for National Statistics death registration data were eligible. Incident IIM cases were identified by the presence of an IIM diagnosis in secondary or primary care during the study period, with date of onset defined at the earliest record of IIM diagnosis in either care setting.
IIM cases were matched up to 1:4 with controls by age, sex, ethnicity, and socioeconomic deprivation. Negative binomial models were used to derive unadjusted Incidence Rate Ratios (IRRs). Study outcomes were the number of all-cause HCU interactions in the 2 years post-diagnosis, including outpatient attendances, accident and emergency visits, hospital admissions and critical care.
RESULTS: We identified 4,097 incident cases of IIM with a median age at diagnosis of 60 years (interquartile range 44-72) and a higher proportion of females (56.4%), matched to n=16,294 controls. IIM was associated with a marked increase in HCU rates across all outcomes compared to controls: outpatient attendances (IRR 5.61, 95% Confidence Interval [CI] 5.29, 5.96), accident and emergency visits (IRR 3.46, 95% CI 3.20, 3.74), hospital admissions (IRR 8.00, 95% CI 7.42, 8.64), and critical care encounters (IRR 8.78, 95% CI 7.30, 10.56).
CONCLUSIONS: People with IIM have substantially increased healthcare utilisation across secondary care in the two years following diagnosis, highlighted by particularly high burden of emergency and critical care encounters. These findings highlight the importance of considering potentially complex healthcare needs in people recently diagnosed with IIM as part of their care programme.
Conference/Value in Health Info
2026-11, ISPOR Europe 2026, Vienna, Austria
Value in Health, Volume 29, Issue 12S
Code
EPH148
Topic
Epidemiology & Public Health, Real World Data & Information Systems
Disease
Systemic Disorders/Conditions (Anesthesia, Auto-Immune Disorders (n.e.c.), Hematological Disorders (non-oncologic), Pain)