HEALTH-RELATED QUALITY OF LIFE BY EQ-5D-5L IN MULTIPLE SCLEROSIS: CHARACTERIZATION AND KEY ADVERSE FACTORS' DISUTILITIES
Author(s)
Amaia Bilbao, PhD1, daniela mestre, PhD2, Idoia Castillo-Sintes, MSc2, José M Quintana, PhD3, Mar Mendibe, PhD4, Alfredo Rodríguez-Antigüedad, PhD4, Iñigo Gorostiza, PhD1.
1Osakidetza Basque Health Service, Basurto University Hospital, Research and Innovation Unit; Biosistemak Institute for Health Systems Research; Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS), Bilbao, Spain, 2Biosistemak Institute for Health Systems Research; Osakidetza Basque Health Service, Basurto University Hospital, Research and Innovation Unit; Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS), Bilbao, Spain, 3Osakidetza Basque Health Service, Galdakao-Usansolo University Hospital, Research Unit; Biosistemak Institute for Health Systems Research; Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS), Galdakao, Spain, 4Osakidetza Basque Health Service, Cruces University Hospital, Neurology Department; Biobizkaia Health Research Institute; Neuroscience Department, Faculty of Nursing and Medicine, University of the Basque Country (EHU), Barakaldo, Spain.
1Osakidetza Basque Health Service, Basurto University Hospital, Research and Innovation Unit; Biosistemak Institute for Health Systems Research; Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS), Bilbao, Spain, 2Biosistemak Institute for Health Systems Research; Osakidetza Basque Health Service, Basurto University Hospital, Research and Innovation Unit; Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS), Bilbao, Spain, 3Osakidetza Basque Health Service, Galdakao-Usansolo University Hospital, Research Unit; Biosistemak Institute for Health Systems Research; Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS), Galdakao, Spain, 4Osakidetza Basque Health Service, Cruces University Hospital, Neurology Department; Biobizkaia Health Research Institute; Neuroscience Department, Faculty of Nursing and Medicine, University of the Basque Country (EHU), Barakaldo, Spain.
OBJECTIVES: 1) to describe health related quality of life (HRQoL) by EQ-5D-5L in a cohort of people with multiple sclerosis (MS), 2) to estimate EQ-5D-5L disutilities associated with key determinants of HRQoL impairment and 3) to compare EQ-5D-5L among PwMS and general population (GP).
METHODS: 135 people with MS, recruited from specialist consultations in two public hospitals from the Basque Country (Spain), completed the EQ-5D-5L. EQ-5D-5L was characterized according to sociodemographic and clinical factors by means of Wilcoxon or Kruskal-Wallis tests. Disutilities of key variables were determined by a two-part statistical model. We compared EQ-5D-5L values between people with MS and GP via t-test.
RESULTS: In people with MS, mean utility index and visual analogical scale (EQ VAS) were 0.753 (SD =0.224) and 68.7 (SD=22), respectively. They both depended on the age, sex, disease duration, disability, MS phenotype and specific symptoms. 48.1%, 23.8%, 60.2%, 60.2% and 54.1% of individuals reported troubles in mobility, self-care, usual activities, pain/discomfort and anxiety/depression dimensions, respectively. Among all the analyzed factors, the ones independently associated with utility decrements were being ≥55 years old, male sex, expanded disability status scale (EDSS) ≥4, fatigue, pain and depression. The corresponding disutility values were -0.183, -0.064, ≥-0.128, -0.069, -0.162, and -0.078, respectively, as compared to the reference groups. EQ-5D-5L values were lower in people with MS than in GP, especially in older males.
CONCLUSIONS: MS negatively affects EQ-5D-5L-assessed HRQoL in this cohort of study, depending on several sociodemographic and clinical factors. Being ≥55 years old, male or presenting moderate disability, pain, fatigue and depression are decisive factors for HRQoL impairment in MS here.
METHODS: 135 people with MS, recruited from specialist consultations in two public hospitals from the Basque Country (Spain), completed the EQ-5D-5L. EQ-5D-5L was characterized according to sociodemographic and clinical factors by means of Wilcoxon or Kruskal-Wallis tests. Disutilities of key variables were determined by a two-part statistical model. We compared EQ-5D-5L values between people with MS and GP via t-test.
RESULTS: In people with MS, mean utility index and visual analogical scale (EQ VAS) were 0.753 (SD =0.224) and 68.7 (SD=22), respectively. They both depended on the age, sex, disease duration, disability, MS phenotype and specific symptoms. 48.1%, 23.8%, 60.2%, 60.2% and 54.1% of individuals reported troubles in mobility, self-care, usual activities, pain/discomfort and anxiety/depression dimensions, respectively. Among all the analyzed factors, the ones independently associated with utility decrements were being ≥55 years old, male sex, expanded disability status scale (EDSS) ≥4, fatigue, pain and depression. The corresponding disutility values were -0.183, -0.064, ≥-0.128, -0.069, -0.162, and -0.078, respectively, as compared to the reference groups. EQ-5D-5L values were lower in people with MS than in GP, especially in older males.
CONCLUSIONS: MS negatively affects EQ-5D-5L-assessed HRQoL in this cohort of study, depending on several sociodemographic and clinical factors. Being ≥55 years old, male or presenting moderate disability, pain, fatigue and depression are decisive factors for HRQoL impairment in MS here.
Conference/Value in Health Info
2026-11, ISPOR Europe 2026, Vienna, Austria
Value in Health, Volume 29, Issue 12S
Code
PCR122
Topic
Patient-Centered Research
Topic Subcategory
Patient-reported Outcomes & Quality of Life Outcomes
Disease
Neurological Disorders