HEALTH-RELATED QUALITY OF LIFE AND ITS INFLUENCING FACTORS IN CHINESE PATIENTS WITH ANKYLOSING SPONDYLITIS: A SYSTEMATIC REVIEW
Author(s)
Yangyang Fan, Bachelor, Jiaqi Shi, Master, Xinyue Yuan, Bachelor, MING HU, PhD.
West China School of Pharmacy, Sichuan University, Chengdu, China.
West China School of Pharmacy, Sichuan University, Chengdu, China.
OBJECTIVES: Ankylosing spondylitis (AS) impairs health, yet health-related quality of life (HRQoL) evidence in Chinese patients lacks synthesis. This review systematically evaluated HRQoL and its determinants.
METHODS: PubMed, Web of Science, Cochrane Library, Embase, CNKI, and Wanfang databases were searched from inception to June 2026 for cross-sectional studies on HRQoL in Chinese AS patients. Two researchers independently screened and extracted data; disagreements were resolved by a third.
RESULTS: 28 studies were included (18 Chinese, 10 English). Studies covered 16 provinces (outpatient/inpatient; one community-based). Sample sizes ranged from 44 to 484. Convenience sampling was used in 25 studies, cluster sampling in three. Patients were predominantly aged 20-40 years, with varying disease durations; 81.48%(22/27) of studies reported >70% males. Generic (SF-36 [15], WHOQOL-BREF [3], EQ-5D [1]) and AS-specific (ASQoL [5], SQOL-AS [2], ASAS-HI [1], EASi-QoL [1]) instruments were used. Patients with active AS had significantly lower HRQoL than the general population and than those with inactive AS. SF-36 showed that, physical function (PF) and role-physical (RP) were the most impaired domains. Most studies also assessed the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI). Only one study developed mapping algorithms from BASDAI/BASFI to the EQ-5D-3L and EQ-5D-5L. A group of Chinese people had EQ‑5D scores (0.74 ± 0.27) that were higher than the global pooled estimate 0.62, and also higher than the estimates for various European countries (ranging from 0.63 to 0.68). BASFI was the strongest predictor of HRQoL, followed by disease activity, disease duration, pain, and psychological issues (e.g., anxiety, depression). Two studies on coping (confrontation, avoidance, resignation) found confrontation linked to better HRQoL, resignation to worse.
CONCLUSIONS: Early rehabilitation and psychological support should be implemented to improve long-term HRQoL. Future studies should adopt mapping methods to convert disease‑specific measures into health utility values to facilitate health economic evaluations.
METHODS: PubMed, Web of Science, Cochrane Library, Embase, CNKI, and Wanfang databases were searched from inception to June 2026 for cross-sectional studies on HRQoL in Chinese AS patients. Two researchers independently screened and extracted data; disagreements were resolved by a third.
RESULTS: 28 studies were included (18 Chinese, 10 English). Studies covered 16 provinces (outpatient/inpatient; one community-based). Sample sizes ranged from 44 to 484. Convenience sampling was used in 25 studies, cluster sampling in three. Patients were predominantly aged 20-40 years, with varying disease durations; 81.48%(22/27) of studies reported >70% males. Generic (SF-36 [15], WHOQOL-BREF [3], EQ-5D [1]) and AS-specific (ASQoL [5], SQOL-AS [2], ASAS-HI [1], EASi-QoL [1]) instruments were used. Patients with active AS had significantly lower HRQoL than the general population and than those with inactive AS. SF-36 showed that, physical function (PF) and role-physical (RP) were the most impaired domains. Most studies also assessed the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI). Only one study developed mapping algorithms from BASDAI/BASFI to the EQ-5D-3L and EQ-5D-5L. A group of Chinese people had EQ‑5D scores (0.74 ± 0.27) that were higher than the global pooled estimate 0.62, and also higher than the estimates for various European countries (ranging from 0.63 to 0.68). BASFI was the strongest predictor of HRQoL, followed by disease activity, disease duration, pain, and psychological issues (e.g., anxiety, depression). Two studies on coping (confrontation, avoidance, resignation) found confrontation linked to better HRQoL, resignation to worse.
CONCLUSIONS: Early rehabilitation and psychological support should be implemented to improve long-term HRQoL. Future studies should adopt mapping methods to convert disease‑specific measures into health utility values to facilitate health economic evaluations.
Conference/Value in Health Info
2026-11, ISPOR Europe 2026, Vienna, Austria
Value in Health, Volume 29, Issue 12S
Code
EPH76
Topic
Epidemiology & Public Health, Patient-Centered Research
Disease
Musculoskeletal Disorders (Arthritis, Bone Disorders, Osteoporosis, Other Musculoskeletal)