BURDEN OF DISEASE IN VON WILLEBRAND DISEASE: EVIDENCE FROM A DANISH NATIONAL REGISTER STUDY
Author(s)
Peter Bo Poulsen, MSc, PhD1, Maria Dybdahl Hammer, MSc2, Jens Olsen, MSc2, Stine Nynne Larsen, MSc1, Maya Friis Kjaergaard, MSc, PhD1.
1Roche Pharmaceuticals a/s, Copenhagen, Denmark, 2EY Parthenon P/S, Frederiksberg, Denmark.
1Roche Pharmaceuticals a/s, Copenhagen, Denmark, 2EY Parthenon P/S, Frederiksberg, Denmark.
OBJECTIVES: To assess the real-world disease burden of von Willebrand disease (VWD) in Denmark, evaluating comorbidities, healthcare resource utilization (HCRU), educational attainment, and societal impact of the disease.
METHODS: This retrospective nationwide register-based cohort study (1994-2024) evaluated incident VWD patients (ICD-10: D68.0). The index date was defined as the first hospital contact. Cases were matched 1:5 with general population controls without a VWD history (by age, sex, region). Data from Danish national registries (National Patient Register, Cause of Death Register, DREAM (labor market data), Educational Register) were linked on the individual level. Descriptive statistics and linear regression compared comorbidities, HCRU, and socioeconomic outcomes between cohorts.
RESULTS: The study identified 967 VWD patients (72% females). Mean index age was 33.6 years (SD: 18.3) for women and 26.3 years (SD: 23.1) for men. Educational attainment was comparable between cohorts. VWD patients exhibited higher comorbidity rates than controls, including hypertension (women: 12.5% vs 7.2%; men: 7.4% vs 6.0%) and shoulder lesions (women: 9.2% vs 5.5%; men: 7.8% vs 3.6%). Dental and pulp diseases (ICD-10: K01, K02, K04) frequently affected VWD men (7.4-10.0%) but not controls. In women, excessive, frequent, and irregular menstruation was the most frequent comorbidity with 25.8% vs 5.3% for controls. Annual HCRU was significantly elevated: VWD patients required 2-3 times more hospitalizations (0.3 inpatient stays annually) and twice the outpatient visits (5-6.8 visits annually) versus controls. The societal impact was profound with VWD patients working less, experiencing longer sick leave (females), and showing significantly higher reliance on early retirement benefits compared to controls (males: 15% vs 10%; females: 10% vs 6%).
CONCLUSIONS: Von Willebrand disease imposes a substantial clinical and societal burden on Danish patients. Despite comparable education, Von Willebrand patients face elevated comorbidity risks, increased HCRU, and greater reliance on social welfare, emphasizing the need for comprehensive disease management.
METHODS: This retrospective nationwide register-based cohort study (1994-2024) evaluated incident VWD patients (ICD-10: D68.0). The index date was defined as the first hospital contact. Cases were matched 1:5 with general population controls without a VWD history (by age, sex, region). Data from Danish national registries (National Patient Register, Cause of Death Register, DREAM (labor market data), Educational Register) were linked on the individual level. Descriptive statistics and linear regression compared comorbidities, HCRU, and socioeconomic outcomes between cohorts.
RESULTS: The study identified 967 VWD patients (72% females). Mean index age was 33.6 years (SD: 18.3) for women and 26.3 years (SD: 23.1) for men. Educational attainment was comparable between cohorts. VWD patients exhibited higher comorbidity rates than controls, including hypertension (women: 12.5% vs 7.2%; men: 7.4% vs 6.0%) and shoulder lesions (women: 9.2% vs 5.5%; men: 7.8% vs 3.6%). Dental and pulp diseases (ICD-10: K01, K02, K04) frequently affected VWD men (7.4-10.0%) but not controls. In women, excessive, frequent, and irregular menstruation was the most frequent comorbidity with 25.8% vs 5.3% for controls. Annual HCRU was significantly elevated: VWD patients required 2-3 times more hospitalizations (0.3 inpatient stays annually) and twice the outpatient visits (5-6.8 visits annually) versus controls. The societal impact was profound with VWD patients working less, experiencing longer sick leave (females), and showing significantly higher reliance on early retirement benefits compared to controls (males: 15% vs 10%; females: 10% vs 6%).
CONCLUSIONS: Von Willebrand disease imposes a substantial clinical and societal burden on Danish patients. Despite comparable education, Von Willebrand patients face elevated comorbidity risks, increased HCRU, and greater reliance on social welfare, emphasizing the need for comprehensive disease management.
Conference/Value in Health Info
2026-11, ISPOR Europe 2026, Vienna, Austria
Value in Health, Volume 29, Issue 12S
Code
EPH99
Topic
Epidemiology & Public Health
Topic Subcategory
Public Health
Disease
Systemic Disorders/Conditions (Anesthesia, Auto-Immune Disorders (n.e.c.), Hematological Disorders (non-oncologic), Pain)