SOCIETAL IMPACT OF A DISEASE - THE CASE OF HEMOPHILIA A. EVIDENCE FROM A DANISH NATIONAL REGISTER STUDY
Author(s)
Peter Bo Poulsen, MSc, PhD1, Maria Dybdahl Hammer, MSc2, Jens Olsen, MSc2, Stine Nynne Larsen, MSc1, Maya Friis Kjaergaard, MSc, PhD1.
1Roche Pharmaceuticals a/s, Copenhagen, Denmark, 2EY Parthenon P/S, Frederiksberg, Denmark.
1Roche Pharmaceuticals a/s, Copenhagen, Denmark, 2EY Parthenon P/S, Frederiksberg, Denmark.
OBJECTIVES: To investigate the healthcare resource use (HCRU) and societal impact of hemophilia A (HA) in Danish women and men.
METHODS: This retrospective, nationwide register-based cohort study (1994-2024) included incident HA patients (ICD-10: D66.9, index = first hospital contact). Cases were matched 1:5 on age, sex and region to general population controls. Linked data from the National Patient Register, Cause of Death Register and DREAM (public database with long-term data on labor market status and public transfers were analyzed). Descriptive statistics and linear regression were applied to compare comorbidities, HCRU, and socioeconomic impacts between cohorts. HA results are presented by gender due to distinct X-linked bleeding and treatment profiles.
RESULTS: The cohort included 627 males (mean age: 27.0, SD: 24.8) and 269 females (mean age: 35.9, SD: 23.4) suffering from HA in the period studied. Among males, 17.1% suffered from chronic viral hepatitis and 13.6% had hypertension compared to 7.1% of controls. For females, 13.8% suffered from excessive, frequent and irregular menstruation compared to 4.7% for controls, and obesity frequency was double that of controls (16%/7.7%). In 2024, HA males required three times more outpatient hospital visits than controls (6.9/2.4; P<0.001) and twice as many hospitalizations (0.28/0.13). Female cases also exhibited significantly elevated HCRU (P<0.001). In terms of societal impact, patients worked fewer weeks in 2024 (males: 33/40; females: 32/37). HA women experienced longer unemployment durations, and HA men had extended sick leave (19.8/13.0 weeks). Early retirement pensions were significantly more prevalent among patients compared to controls (males: 16%/7%; females: 12%/8%).
CONCLUSIONS: The healthcare resource use and societal impact of the hemophilia A disease is substantial for both sexes in Denmark. Especially in regard to hospital contacts, earlier retirement rate, but also lower work presence. Hemophilia A patients face higher comorbidity rates than the general population, e.g. hypertension and obesity rates.
METHODS: This retrospective, nationwide register-based cohort study (1994-2024) included incident HA patients (ICD-10: D66.9, index = first hospital contact). Cases were matched 1:5 on age, sex and region to general population controls. Linked data from the National Patient Register, Cause of Death Register and DREAM (public database with long-term data on labor market status and public transfers were analyzed). Descriptive statistics and linear regression were applied to compare comorbidities, HCRU, and socioeconomic impacts between cohorts. HA results are presented by gender due to distinct X-linked bleeding and treatment profiles.
RESULTS: The cohort included 627 males (mean age: 27.0, SD: 24.8) and 269 females (mean age: 35.9, SD: 23.4) suffering from HA in the period studied. Among males, 17.1% suffered from chronic viral hepatitis and 13.6% had hypertension compared to 7.1% of controls. For females, 13.8% suffered from excessive, frequent and irregular menstruation compared to 4.7% for controls, and obesity frequency was double that of controls (16%/7.7%). In 2024, HA males required three times more outpatient hospital visits than controls (6.9/2.4; P<0.001) and twice as many hospitalizations (0.28/0.13). Female cases also exhibited significantly elevated HCRU (P<0.001). In terms of societal impact, patients worked fewer weeks in 2024 (males: 33/40; females: 32/37). HA women experienced longer unemployment durations, and HA men had extended sick leave (19.8/13.0 weeks). Early retirement pensions were significantly more prevalent among patients compared to controls (males: 16%/7%; females: 12%/8%).
CONCLUSIONS: The healthcare resource use and societal impact of the hemophilia A disease is substantial for both sexes in Denmark. Especially in regard to hospital contacts, earlier retirement rate, but also lower work presence. Hemophilia A patients face higher comorbidity rates than the general population, e.g. hypertension and obesity rates.
Conference/Value in Health Info
2026-11, ISPOR Europe 2026, Vienna, Austria
Value in Health, Volume 29, Issue 12S
Code
EPH41
Topic
Epidemiology & Public Health
Topic Subcategory
Public Health
Disease
Systemic Disorders/Conditions (Anesthesia, Auto-Immune Disorders (n.e.c.), Hematological Disorders (non-oncologic), Pain)