MULTIDIMENSIONAL BURDEN OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) ON HEALTH-RELATED QUALITY OF LIFE (HRQOL) AND FAMILY IMPACT IN ALGERIA: A PHYSICIAN REPORTED ASSESSMENT
Author(s)
Soraya DJEMAI, PharmD1, Rachida Khelafi, Professor2, Gharnaout Merzak, Professor2, Abd el Bassat Ketfi, Professor2, Souad Souilah, Professor2, Samir Benamar, Professor3, Lila Ihadjadene, PhD4, Sara Firane, PhD5.
1Market Access, Sanofi, Algiers, Algeria, 2University of Health Sciences, Algiers, Algeria, 3CHU Tlemcen, Tlemcen, Algeria, 4CHU TIZI OUZOU, Tizi Ouzou, Algeria, 5EPH Blida, Blida, Algeria.
1Market Access, Sanofi, Algiers, Algeria, 2University of Health Sciences, Algiers, Algeria, 3CHU Tlemcen, Tlemcen, Algeria, 4CHU TIZI OUZOU, Tizi Ouzou, Algeria, 5EPH Blida, Blida, Algeria.
OBJECTIVES: COPD is a major cause of morbidity and mortality, and patients at high risk of exacerbations suffer from worse symptoms and poorer overall health status. This study assesses the impact of COPD on patients’ HRQoL and their families in Algeria, and compares outcomes across clinical phenotypes.
METHODS: A cross-sectional analysis was conducted using data from semi-structured interviews with 12 pneumologists across seven hospitals, reporting on patients managed over 12 months. HRQoL was assessed using a physician-reported multidimensional approach covering mobility, autonomy, daily activities, sleep, respiratory pain/discomfort, and anxiety/depression. Impact was quantified using a 0-4 scale (0 = no impact; 4 = extreme), and a global QoL index was calculated, with higher scores indicating worse HRQoL. Family impact was evaluated through physician-reported estimates, including time commitment, emotional burden, professional adjustments, and financial constraints. Outcomes were compared between patients with low exacerbation risk (Groups A&B) and frequent exacerbators (Group E), according to GOLD 2023 classification.
RESULTS: COPD was associated with marked impairment in QoL. Differences between Groups A&B and Group E were statistically significant across all domains (p<0.001), with higher proportions of moderate to extreme impact in Group E, driving a higher global QoL index (2.12 vs. 0.95) reflecting 123% greater impairment. This was associated with increased patient dependency, with 47% of Group E patients requiring accompaniment compared to 15% in Groups A&B (p<0.001). Consistently, families were more impacted among Group E patients, in terms of time commitment (73% vs 22%), work adjustments (20% vs 2%), and financial impact (55% vs 24%) (all p<0.001) while emotional burden did not differ significantly between groups.
CONCLUSIONS: COPD imposes a significant multidimensional burden on HRQoL in Algeria, particularly among frequent exacerbators. This physician-reported approach provides valuable real-world insights in settings where local data remain limited, while validated patient-reported instruments could improve the assessment and comparability with international evidence.
METHODS: A cross-sectional analysis was conducted using data from semi-structured interviews with 12 pneumologists across seven hospitals, reporting on patients managed over 12 months. HRQoL was assessed using a physician-reported multidimensional approach covering mobility, autonomy, daily activities, sleep, respiratory pain/discomfort, and anxiety/depression. Impact was quantified using a 0-4 scale (0 = no impact; 4 = extreme), and a global QoL index was calculated, with higher scores indicating worse HRQoL. Family impact was evaluated through physician-reported estimates, including time commitment, emotional burden, professional adjustments, and financial constraints. Outcomes were compared between patients with low exacerbation risk (Groups A&B) and frequent exacerbators (Group E), according to GOLD 2023 classification.
RESULTS: COPD was associated with marked impairment in QoL. Differences between Groups A&B and Group E were statistically significant across all domains (p<0.001), with higher proportions of moderate to extreme impact in Group E, driving a higher global QoL index (2.12 vs. 0.95) reflecting 123% greater impairment. This was associated with increased patient dependency, with 47% of Group E patients requiring accompaniment compared to 15% in Groups A&B (p<0.001). Consistently, families were more impacted among Group E patients, in terms of time commitment (73% vs 22%), work adjustments (20% vs 2%), and financial impact (55% vs 24%) (all p<0.001) while emotional burden did not differ significantly between groups.
CONCLUSIONS: COPD imposes a significant multidimensional burden on HRQoL in Algeria, particularly among frequent exacerbators. This physician-reported approach provides valuable real-world insights in settings where local data remain limited, while validated patient-reported instruments could improve the assessment and comparability with international evidence.
Conference/Value in Health Info
2026-11, ISPOR Europe 2026, Vienna, Austria
Value in Health, Volume 29, Issue 12S
Code
PCR36
Topic
Patient-Centered Research
Topic Subcategory
Patient-reported Outcomes & Quality of Life Outcomes
Disease
No Additional Disease & Conditions/Specialized Treatment Areas, Respiratory-Related Disorders (Allergy, Asthma, Smoking, Other Respiratory)