HIGH-FREQUENCY PROMS WITH INTEGRATION INTO ELECTRONIC HEALTH RECORDS: A NOVEL CLINICAL OUTCOME
Author(s)
Martin Dugas, Prof. Dr..
Heidelberg University Medical Faculty, Heidelberg, Germany.
Heidelberg University Medical Faculty, Heidelberg, Germany.
OBJECTIVES: To develop and evaluate technical feasibility and clinical validity of a digital system that captures Patient Reported Outcome Measures (PROMs) with high frequency via mobile devices and integrates them directly into electronic health records (EHRs) for clinical care and research.
METHODS: A secure IT architecture was implemented using a web-based application (MyEDC). Patients received automated E-mails (daily and weekly) containing unique links to complete PROMs on personal mobile devices. For information security, the app communicated with an electronic data capture proxy in the hospital’s demilitarized zone, protected by firewalls. The system was validated over two weeks to three months across four clinical cohorts: psychosomatics, hematology, visceral surgery, and neurosurgery. Feasibility was assessed through completion rates and validity by comparison with established outcome measures.
RESULTS: High-frequency PROMs were successfully collected for 110 patients. The system demonstrated feasibility; median response times ranged from 0.9 to 7.1 hours, with no significant correlation between completion and patient age. In psychosomatics (n=36), a significant increase in overall well-being was captured following four weeks of therapy (median 42% to 60%, P=.01). In hematology (n=25), high-resolution PROMs correlated with standard QLQ-C30 global scores (P=.02). In visceral surgery (n=26), an inverse association was established between overall well-being and pain (P<.001). High-frequency PROMs proved valid and revealed significant intra- and inter-individual variability that would have been missed by traditional assessments. Completion rates remained high, indicating strong patient engagement. Clinicians reported that high-frequency PROMs facilitated a more nuanced understanding of patient recovery.
CONCLUSIONS: High-frequency PROMs with EHR integration are technically viable and clinically valid. Moving beyond static patient outcomes, high-frequency PROMs provide a novel readout that enables precise, near-real-time disease characterization and enhances personalized medicine in clinical care and research.
Reference https://doi.org/10.2196/79834
METHODS: A secure IT architecture was implemented using a web-based application (MyEDC). Patients received automated E-mails (daily and weekly) containing unique links to complete PROMs on personal mobile devices. For information security, the app communicated with an electronic data capture proxy in the hospital’s demilitarized zone, protected by firewalls. The system was validated over two weeks to three months across four clinical cohorts: psychosomatics, hematology, visceral surgery, and neurosurgery. Feasibility was assessed through completion rates and validity by comparison with established outcome measures.
RESULTS: High-frequency PROMs were successfully collected for 110 patients. The system demonstrated feasibility; median response times ranged from 0.9 to 7.1 hours, with no significant correlation between completion and patient age. In psychosomatics (n=36), a significant increase in overall well-being was captured following four weeks of therapy (median 42% to 60%, P=.01). In hematology (n=25), high-resolution PROMs correlated with standard QLQ-C30 global scores (P=.02). In visceral surgery (n=26), an inverse association was established between overall well-being and pain (P<.001). High-frequency PROMs proved valid and revealed significant intra- and inter-individual variability that would have been missed by traditional assessments. Completion rates remained high, indicating strong patient engagement. Clinicians reported that high-frequency PROMs facilitated a more nuanced understanding of patient recovery.
CONCLUSIONS: High-frequency PROMs with EHR integration are technically viable and clinically valid. Moving beyond static patient outcomes, high-frequency PROMs provide a novel readout that enables precise, near-real-time disease characterization and enhances personalized medicine in clinical care and research.
Reference https://doi.org/10.2196/79834
Conference/Value in Health Info
2026-11, ISPOR Europe 2026, Vienna, Austria
Value in Health, Volume 29, Issue 12S
Code
CO25
Topic
Clinical Outcomes, Patient-Centered Research, Real World Data & Information Systems
Topic Subcategory
Clinical Outcomes Assessment
Disease
Gastrointestinal Disorders, Mental Health (including addiction), Musculoskeletal Disorders (Arthritis, Bone Disorders, Osteoporosis, Other Musculoskeletal), Oncology