COMPARATIVE ANALYSIS OF DIETARY PATTERN, DIGESTIVE SYMPTOMS AND HEALTH-RELATED QUALITY OF LIFE IN MIDDLE-AGED AND ELDERLY PATIENTS DIAGNOSED WITH IRRITABLE BOWEL SYNDROME
Author(s)
Shravani S. Wagh, PHARM.D1, DIPAK PURI, PHARM.D PB2, Khushi Undale, PHARM.D3, Aswathy Sivanandan, PHARM.D3, Haritha S. Nath, PharmD3, VIKAS BHARTI, MBBS, MD Medicine, DNB Medical Gastroenterology4.
1Student, Dr. D.Y. Patil Dnyan Prasad University's School of Pharmacy and Research, Pune, Pimpri, India, 2Dr. D.Y. Patil Dnyan Prasad University's School of Pharmacy and Research, Pune, PUNE, India, 3Dr. D.Y. Patil Dnyan Prasad University's School of Pharmacy and Research, Pune, Pune, India, 4Dr. D.Y. Patil Medical College Hospital and Research Centre,Pune, PUNE, India.
1Student, Dr. D.Y. Patil Dnyan Prasad University's School of Pharmacy and Research, Pune, Pimpri, India, 2Dr. D.Y. Patil Dnyan Prasad University's School of Pharmacy and Research, Pune, PUNE, India, 3Dr. D.Y. Patil Dnyan Prasad University's School of Pharmacy and Research, Pune, Pune, India, 4Dr. D.Y. Patil Medical College Hospital and Research Centre,Pune, PUNE, India.
OBJECTIVES: To determine the relationship between dietary pattern and severity of gastrointestinal symptoms with Health- Related Quality of Life in IBS patients, and to determine the relationship between dietary risk, symptom severity, and health-related quality of life (HRQoL).
METHODS: A single-centre, cross-sectional study enrolled 147 consecutive Rome IV-diagnosed IBS patients (93 middle-aged [40-59 years], 54 elderly [60 years and above]) at a tertiary-care gastroenterology outpatient department over 6 months. Dietary patterns were assessed using an investigator-developed Dietary Pattern Assessment Questionnaire (DPAQ), symptom severity via the IBS Symptom Severity Score (IBS-SSS), and HRQoL via the Gastrointestinal Quality of Life Index-10 (GIQLI-10). Data were analyzed using descriptive statistics, two-way ANOVA (age category by IBS subtype on IBS-SSS), Pearson correlation, bivariate linear regression, and age-stratified regression.
RESULTS: IBS subtypes were distributed as IBS-C 34%, IBS-D 34%, IBS-M 17%, and IBS-U 15%. Most patients (63%) had moderate-to-high dietary risk. Two-way ANOVA showed neither age category (F[1,139]=0.589, p=0.444) nor IBS subtype (F[3,139]=0.455, p=0.714) significantly predicted symptom severity; the age-by-subtype interaction was also non-significant (p=0.097). Dietary risk showed a near-perfect positive correlation with symptom severity (r=0.97, R²=0.949, p<0.001) and a strong negative correlation with HRQoL (r=-0.76, R²=0.571, p<0.001); symptom severity also correlated strongly and negatively with HRQoL (r=-0.83, R²=0.684, p<0.001). Age-stratified regression showed the dietary risk-severity relationship was stronger in elderly (R²=0.988) than middle-aged (R²=0.967) patients, with steeper symptom escalation per unit dietary risk among the elderly. Most patients (87.8%) reported moderate-to-good HRQoL.
CONCLUSIONS: Dietary risk, not age category or clinical subtype, was the dominant determinant of symptom severity and HRQoL in this IBS population, with a steeper dose-response relationship in elderly patients. These findings support age-tailored dietary counseling as a targeted, low-cost intervention strategy for IBS symptom and HRQoL management.
METHODS: A single-centre, cross-sectional study enrolled 147 consecutive Rome IV-diagnosed IBS patients (93 middle-aged [40-59 years], 54 elderly [60 years and above]) at a tertiary-care gastroenterology outpatient department over 6 months. Dietary patterns were assessed using an investigator-developed Dietary Pattern Assessment Questionnaire (DPAQ), symptom severity via the IBS Symptom Severity Score (IBS-SSS), and HRQoL via the Gastrointestinal Quality of Life Index-10 (GIQLI-10). Data were analyzed using descriptive statistics, two-way ANOVA (age category by IBS subtype on IBS-SSS), Pearson correlation, bivariate linear regression, and age-stratified regression.
RESULTS: IBS subtypes were distributed as IBS-C 34%, IBS-D 34%, IBS-M 17%, and IBS-U 15%. Most patients (63%) had moderate-to-high dietary risk. Two-way ANOVA showed neither age category (F[1,139]=0.589, p=0.444) nor IBS subtype (F[3,139]=0.455, p=0.714) significantly predicted symptom severity; the age-by-subtype interaction was also non-significant (p=0.097). Dietary risk showed a near-perfect positive correlation with symptom severity (r=0.97, R²=0.949, p<0.001) and a strong negative correlation with HRQoL (r=-0.76, R²=0.571, p<0.001); symptom severity also correlated strongly and negatively with HRQoL (r=-0.83, R²=0.684, p<0.001). Age-stratified regression showed the dietary risk-severity relationship was stronger in elderly (R²=0.988) than middle-aged (R²=0.967) patients, with steeper symptom escalation per unit dietary risk among the elderly. Most patients (87.8%) reported moderate-to-good HRQoL.
CONCLUSIONS: Dietary risk, not age category or clinical subtype, was the dominant determinant of symptom severity and HRQoL in this IBS population, with a steeper dose-response relationship in elderly patients. These findings support age-tailored dietary counseling as a targeted, low-cost intervention strategy for IBS symptom and HRQoL management.
Conference/Value in Health Info
2026-11, ISPOR Europe 2026, Vienna, Austria
Value in Health, Volume 29, Issue 12S
Code
PCR8
Topic
Clinical Outcomes, Patient-Centered Research, Study Approaches
Topic Subcategory
Health State Utilities, Patient-reported Outcomes & Quality of Life Outcomes
Disease
Gastrointestinal Disorders, Geriatrics, No Additional Disease & Conditions/Specialized Treatment Areas