CHARACTERIZING THE MULTI-DIMENSIONAL BURDEN OF DISEASE AND GAPS IN SUPPORT AMONG PEOPLE WITH OBESITY UTILISING GLP-1 RECEPTOR AGONISTS
Author(s)
João Fernandes, MSc1, Timothy Arnaut, MSc1, Julie Hahn-Pedersen, MSc1, Daniele Montalto, MSc2, Amira Abdelkhalik, MSc2, Ramota Alaran, PhD2, Freddy Green, MSc2.
1Novo Nordisk A/S, Søborg, Denmark, 2Ipsos UK, London, United Kingdom.
1Novo Nordisk A/S, Søborg, Denmark, 2Ipsos UK, London, United Kingdom.
OBJECTIVES: To evaluate the disease burden, weight management attempts and the nature of support systems for individuals overweight or with obesity (PwO).
METHODS: A 20-minute online self-administered bespoke survey was conducted among adults with a BMI ≥ 25kg/m2 across the United Kingdom (UK), Brazil and the Kingdom of Saudi Arabia (KSA). To examine the burden, the sample was segmented into GLP-1 users (defined as current or past users) vs non-users (including those aware and those not aware of GLP-1s). Data were collected on weight-related health burden, historical weight management attempts and the role of healthcare providers (HCP) versus informal support networks.
RESULTS: The study included 2,717 respondents across the UK (n=1,066), KSA (n=886), and Brazil (n=765), comprising 602 GLP-1 users and 2,115 non-users. The average age of participants was 44 years, with the majority male (59%), and a mean BMI of 32kg/m2. Users reported unhappiness with their current weight significantly more than non-users, with 30% of users indicating being very unhappy compared to 24% of non-users. Most respondents have tried different approaches for weight loss such as diet-related actions (58%) and physical activity (43%), however, they face lack of support particularly from HCPs with only 21% receiving support from HCPs and 41% from family and friends. Common weight management challenges included maintaining motivation over time (28%), managing physical hunger (24%) and managing stress or emotional eating (19%).
CONCLUSIONS: At baseline, GLP-1 users report a significantly higher dissatisfaction with their weight compared to non-users which may have motivated them to try a GLP-1 treatment. A history of unsuccessful weight management and heavy reliance on informal support highlight critical gaps in formal care. To improve long-term outcomes with weight management treatments, comprehensive support should be provided that includes clinical strategies and HCP-led interventions to address persistent behavioural challenges like emotional eating and waning motivation.
METHODS: A 20-minute online self-administered bespoke survey was conducted among adults with a BMI ≥ 25kg/m2 across the United Kingdom (UK), Brazil and the Kingdom of Saudi Arabia (KSA). To examine the burden, the sample was segmented into GLP-1 users (defined as current or past users) vs non-users (including those aware and those not aware of GLP-1s). Data were collected on weight-related health burden, historical weight management attempts and the role of healthcare providers (HCP) versus informal support networks.
RESULTS: The study included 2,717 respondents across the UK (n=1,066), KSA (n=886), and Brazil (n=765), comprising 602 GLP-1 users and 2,115 non-users. The average age of participants was 44 years, with the majority male (59%), and a mean BMI of 32kg/m2. Users reported unhappiness with their current weight significantly more than non-users, with 30% of users indicating being very unhappy compared to 24% of non-users. Most respondents have tried different approaches for weight loss such as diet-related actions (58%) and physical activity (43%), however, they face lack of support particularly from HCPs with only 21% receiving support from HCPs and 41% from family and friends. Common weight management challenges included maintaining motivation over time (28%), managing physical hunger (24%) and managing stress or emotional eating (19%).
CONCLUSIONS: At baseline, GLP-1 users report a significantly higher dissatisfaction with their weight compared to non-users which may have motivated them to try a GLP-1 treatment. A history of unsuccessful weight management and heavy reliance on informal support highlight critical gaps in formal care. To improve long-term outcomes with weight management treatments, comprehensive support should be provided that includes clinical strategies and HCP-led interventions to address persistent behavioural challenges like emotional eating and waning motivation.
Conference/Value in Health Info
2026-11, ISPOR Europe 2026, Vienna, Austria
Value in Health, Volume 29, Issue 12S
Code
PCR4
Topic
Patient-Centered Research
Topic Subcategory
Patient Behavior and Incentives
Disease
Diabetes/Endocrine/Metabolic Disorders (including obesity), No Additional Disease & Conditions/Specialized Treatment Areas