Disease and Economic Burden of Dengue in Colombia, 2018-2022
Author(s)
Nelson José Alvis Zakzuk, MSc1, MARIA CARRASQUILLA SOTOMAYOR, BEc, MSc2, Nelson Rafael Alvis Zakzuk, MBA3, Fernando Gómez De la Rosa, BA, MSc4, Nelson Alvis-Guzman, MPH, PhD, MD5.
1Universidad de la Costa, Barranquilla, Colombia, 2Researcher, ALZAK, São Paulo, Brazil, 3ALZAK, Cartagena, Colombia, 4Institución Universitaria Mayor de Cartagena, Cartagena, Colombia, 5Universidad de Cartagena, Cartagena, Colombia.
1Universidad de la Costa, Barranquilla, Colombia, 2Researcher, ALZAK, São Paulo, Brazil, 3ALZAK, Cartagena, Colombia, 4Institución Universitaria Mayor de Cartagena, Cartagena, Colombia, 5Universidad de Cartagena, Cartagena, Colombia.
OBJECTIVES: To estimate the years of life lost (YLL) and productive YLL (PYLL) owing to dengue in Colombia.
METHODS: We gathered mortality data on dengue and population data from the Colombian statistics bureau (DANE). YLL were estimated using the Global Burden of Disease of 2021 methodology, by sex and age groups. YLLs were calculated multiplying total deaths times the life expectancy of each group. Estimates were corrected using the mean of period correction. Two scenarios were considered in evaluating PYLLs to estimate the cost of premature mortality (indirect costs): 1) A lower estimate: Using the 2023 annual minimum wage; 2) A higher estimate: based on the country's 2023 GDP per capita. All costs were expressed in 2023 US dollars.
RESULTS: A total of 608 deaths due to dengue occurred from 2018 to 2022 in Colombia. Dengue deaths during all the period totalized 36,579 YLLs, representing 14.6 YLLs per 100,000 population. The year with the YLL rate was 2019 with 13.5 per 100,000. In 2020, the YLL rate was 7.4, showing an increasing trend up to 2022 (9.1 and 10.7 per 100,000, respectively). Between 2018-2022, occurred 345 deaths owing to dengue in men and 263 in women. Average YLL rate in men was 16.4 per 100,000 and in women was 12.9. Individuals from 0 to 4 years old depicted the greatest YLL rates per 100,000 for all the analyzed period (2018: 54.4, 2019: 82.3, 2020: 39.6, 2021: 28.6, 2022: 33.2), followed by the 5-9 age group. The five-year period totalized indirect costs due to dengue ranging from US$133,226,147 to US$255,290,183.
CONCLUSIONS: YLL rates due to dengue before COVID-19 pandemic were lower than post-pandemic rates. Individuals between 0-9 years old produced the majority of YLLs owing to dengue. Dengue causes important indirect costs due to premature mortality, mainly explained by loses in early age groups.
METHODS: We gathered mortality data on dengue and population data from the Colombian statistics bureau (DANE). YLL were estimated using the Global Burden of Disease of 2021 methodology, by sex and age groups. YLLs were calculated multiplying total deaths times the life expectancy of each group. Estimates were corrected using the mean of period correction. Two scenarios were considered in evaluating PYLLs to estimate the cost of premature mortality (indirect costs): 1) A lower estimate: Using the 2023 annual minimum wage; 2) A higher estimate: based on the country's 2023 GDP per capita. All costs were expressed in 2023 US dollars.
RESULTS: A total of 608 deaths due to dengue occurred from 2018 to 2022 in Colombia. Dengue deaths during all the period totalized 36,579 YLLs, representing 14.6 YLLs per 100,000 population. The year with the YLL rate was 2019 with 13.5 per 100,000. In 2020, the YLL rate was 7.4, showing an increasing trend up to 2022 (9.1 and 10.7 per 100,000, respectively). Between 2018-2022, occurred 345 deaths owing to dengue in men and 263 in women. Average YLL rate in men was 16.4 per 100,000 and in women was 12.9. Individuals from 0 to 4 years old depicted the greatest YLL rates per 100,000 for all the analyzed period (2018: 54.4, 2019: 82.3, 2020: 39.6, 2021: 28.6, 2022: 33.2), followed by the 5-9 age group. The five-year period totalized indirect costs due to dengue ranging from US$133,226,147 to US$255,290,183.
CONCLUSIONS: YLL rates due to dengue before COVID-19 pandemic were lower than post-pandemic rates. Individuals between 0-9 years old produced the majority of YLLs owing to dengue. Dengue causes important indirect costs due to premature mortality, mainly explained by loses in early age groups.
Conference/Value in Health Info
2025-05, ISPOR 2025, Montréal, Quebec, CA
Value in Health, Volume 28, Issue S1
Code
EPH144
Topic
Epidemiology & Public Health
Topic Subcategory
Public Health
Disease
SDC: Infectious Disease (non-vaccine)