HEALTH-RELATED QUALITY OF LIFE TRAJECTORIES AFTER ACUTE STROKE: A 90-DAY PROSPECTIVE LONGITUDINAL COHORT STUDY
Author(s)
Hien Thi-Thu Pham, PhD1, Nguyen Thi-Hong Tran, MSc2, Doan Thi-Hong Duong, MSc3, Yen Thi Hai Nguyen, PhD4, Thanh Dinh Le, PhD5.
1Head of Pharmacy Department, Thong Nhat Hospital, Ho Chi Minh City, Viet Nam, 2University of Medicine and Pharmacy at Ho Chi Minh city, Ho Chi Minh City, Viet Nam, 3University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh, Viet Nam, 4Department of Pharmaceutical Administration, University of Medicine and Pharmacy at Ho Chi Minh city, Ho Chi Minh, Viet Nam, 5Thong Nhat Hospital, Ho Chi Minh, Viet Nam.
1Head of Pharmacy Department, Thong Nhat Hospital, Ho Chi Minh City, Viet Nam, 2University of Medicine and Pharmacy at Ho Chi Minh city, Ho Chi Minh City, Viet Nam, 3University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh, Viet Nam, 4Department of Pharmaceutical Administration, University of Medicine and Pharmacy at Ho Chi Minh city, Ho Chi Minh, Viet Nam, 5Thong Nhat Hospital, Ho Chi Minh, Viet Nam.
OBJECTIVES: Health-related quality of life (HRQoL) is an important patient-centred outcome after stroke. However, evidence on longitudinal HRQoL trajectories and their determinants in Vietnam remains limited. This study aimed to describe changes in HRQoL over the first 90 days after stroke and identify factors associated with HRQoL trajectories using the Vietnamese Stroke Impact Scale 3.0 (SIS 3.0).
METHODS: A prospective longitudinal cohort study was conducted among patients with acute ischemic or hemorrhagic stroke admitted to Thong Nhat Hospital between March and June 2025. HRQoL was assessed using the Vietnamese SIS 3.0 at admission, 30 days, and 90 days after stroke. Changes in SIS scores over time were evaluated using the Friedman test. Factors associated with HRQoL trajectories were examined using linear mixed-effects models adjusting for sociodemographic, clinical, lifestyle, comorbidity, and treatment-related variables. Sensitivity analyses were performed.
RESULTS: A total of 187 patients with stroke were included. The mean total SIS score increased significantly from 57.9 (SD=28.4) at baseline to 68.0 (SD=24.9) at 30 days and 81.3 (SD=27.2) at 90 days (p<0.001). The largest improvements were observed in Social Participation (+37.5 points), Stroke Recovery (+33.9 points), and Mobility (+31.3 points). At 90 days, 50.0% of patients achieved clinically meaningful improvement (MCID ≥15 points), whereas 42.3% remained stable and 7.7% worsened. Multivariable analysis identified ischemic stroke subtype, middle economic status, length of hospitalization, and anticoagulant use as independent factors associated with HRQoL trajectories. Physical and mobility domains recovered more rapidly than cognitive and emotional domains.
CONCLUSIONS: HRQoL improved substantially during the first 90 days after stroke. Stroke subtype, hospitalization duration, economic status, and anticoagulant use were significant determinants of HRQoL trajectories. Routine assessment of stroke-specific HRQoL may support targeted rehabilitation planning.
METHODS: A prospective longitudinal cohort study was conducted among patients with acute ischemic or hemorrhagic stroke admitted to Thong Nhat Hospital between March and June 2025. HRQoL was assessed using the Vietnamese SIS 3.0 at admission, 30 days, and 90 days after stroke. Changes in SIS scores over time were evaluated using the Friedman test. Factors associated with HRQoL trajectories were examined using linear mixed-effects models adjusting for sociodemographic, clinical, lifestyle, comorbidity, and treatment-related variables. Sensitivity analyses were performed.
RESULTS: A total of 187 patients with stroke were included. The mean total SIS score increased significantly from 57.9 (SD=28.4) at baseline to 68.0 (SD=24.9) at 30 days and 81.3 (SD=27.2) at 90 days (p<0.001). The largest improvements were observed in Social Participation (+37.5 points), Stroke Recovery (+33.9 points), and Mobility (+31.3 points). At 90 days, 50.0% of patients achieved clinically meaningful improvement (MCID ≥15 points), whereas 42.3% remained stable and 7.7% worsened. Multivariable analysis identified ischemic stroke subtype, middle economic status, length of hospitalization, and anticoagulant use as independent factors associated with HRQoL trajectories. Physical and mobility domains recovered more rapidly than cognitive and emotional domains.
CONCLUSIONS: HRQoL improved substantially during the first 90 days after stroke. Stroke subtype, hospitalization duration, economic status, and anticoagulant use were significant determinants of HRQoL trajectories. Routine assessment of stroke-specific HRQoL may support targeted rehabilitation planning.
Conference/Value in Health Info
2026-09, ISPOR Asia Pacific 2026, Bangkok, Thailand
Value in Health, Volume 55, Issue S1
Code
PCR25
Topic
Patient-Centered Research
Topic Subcategory
Patient-reported Outcomes & Quality of Life Outcomes
Disease
No Additional Disease & Conditions/Specialized Treatment Areas, SDC: Cardiovascular Disorders (including MI, Stroke, Circulatory)