REAL-WORLD EVALUATION OF TREATMENT ADHERENCE, HEALTHCARE ACCESS, AND PATIENT-CENTRED OUTCOMES IN ANEMIA MANAGEMENT AMONG DIALYSIS-DEPENDENT CHRONIC KIDNEY DISEASE PATIENTS
Author(s)
GAUTAM SAHU, MS, PhD1, Sandeep Arora, MS, PhD2, Tapan Behl, MS, PhD2.
1Assistant Professor, Amity Institute of Pharmacy, Amity University Punjab, Mohali, Punjab, India, MOHALI, India, 2Pharmacy, Amity Institute of Pharmacy, Amity University Punjab, Mohali, Punjab, India, MOHALI, India.
1Assistant Professor, Amity Institute of Pharmacy, Amity University Punjab, Mohali, Punjab, India, MOHALI, India, 2Pharmacy, Amity Institute of Pharmacy, Amity University Punjab, Mohali, Punjab, India, MOHALI, India.
OBJECTIVES: Anemia is a major complication among dialysis-dependent chronic kidney disease (DD-CKD) patients, adversely affecting health-related quality of life (HRQoL), treatment adherence, and healthcare costs. Real-world evidence (RWE) and patient-centered outcomes are increasingly important in healthcare decision-making. This study aimed to evaluate knowledge, attitude, and practice (KAP) regarding anemia management among DD-CKD patients, with emphasis on affordability, accessibility, treatment adherence, and patient-reported outcomes.
METHODS: A cross-sectional real-world study was conducted among DD-CKD patients receiving maintenance hemodialysis at a tertiary care teaching hospital. A structured and validated questionnaire-based survey was administered through direct patient interviews. Demographic, socioeconomic, clinical, and treatment-related information was collected. Knowledge was assessed using closed-ended questions, attitude through a 5-point Likert scale, and practice using adherence and healthcare utilization patterns. Clinical and biochemical parameters were obtained from medical records. Descriptive statistics, chi-square tests, and correlation analyses were performed.
RESULTS: A total of 276 DD-CKD patients participated, including 176 males (63.8%) and 100 females (36.2%). Good knowledge regarding anemia management was observed in 168 patients (60.9%), while 198 patients (71.7%) demonstrated a positive attitude toward treatment adherence. However, only 131 patients (47.5%) reported adequate treatment practices. Controlled hemoglobin levels (≥10 g/dL) were observed in 119 patients (43.1%). Treatment-related financial burden significantly affected healthcare decisions in 201 patients (72.8%). A significant association was observed between patient knowledge and treatment adherence (χ²=9.82; p=0.004). Positive correlation was identified between adherence and improved HRQoL outcomes (r=0.61; p<0.001).
CONCLUSIONS: The study highlights a substantial knowledge-practice gap among DD-CKD patients. Despite favorable awareness and attitudes, affordability constraints and healthcare accessibility barriers negatively affected treatment adherence and outcomes. Integrating patient-centered care, RWE, and HEOR approaches may improve equitable access, HRQoL, and long-term sustainability in CKD anemia management.
METHODS: A cross-sectional real-world study was conducted among DD-CKD patients receiving maintenance hemodialysis at a tertiary care teaching hospital. A structured and validated questionnaire-based survey was administered through direct patient interviews. Demographic, socioeconomic, clinical, and treatment-related information was collected. Knowledge was assessed using closed-ended questions, attitude through a 5-point Likert scale, and practice using adherence and healthcare utilization patterns. Clinical and biochemical parameters were obtained from medical records. Descriptive statistics, chi-square tests, and correlation analyses were performed.
RESULTS: A total of 276 DD-CKD patients participated, including 176 males (63.8%) and 100 females (36.2%). Good knowledge regarding anemia management was observed in 168 patients (60.9%), while 198 patients (71.7%) demonstrated a positive attitude toward treatment adherence. However, only 131 patients (47.5%) reported adequate treatment practices. Controlled hemoglobin levels (≥10 g/dL) were observed in 119 patients (43.1%). Treatment-related financial burden significantly affected healthcare decisions in 201 patients (72.8%). A significant association was observed between patient knowledge and treatment adherence (χ²=9.82; p=0.004). Positive correlation was identified between adherence and improved HRQoL outcomes (r=0.61; p<0.001).
CONCLUSIONS: The study highlights a substantial knowledge-practice gap among DD-CKD patients. Despite favorable awareness and attitudes, affordability constraints and healthcare accessibility barriers negatively affected treatment adherence and outcomes. Integrating patient-centered care, RWE, and HEOR approaches may improve equitable access, HRQoL, and long-term sustainability in CKD anemia management.
Conference/Value in Health Info
2026-09, ISPOR Asia Pacific 2026, Bangkok, Thailand
Value in Health, Volume 55, Issue S1
Code
PCR11
Topic
Patient-Centered Research
Disease
No Additional Disease & Conditions/Specialized Treatment Areas, SDC: Systemic Disorders/Conditions (Anesthesia, Auto-Immune Disorders (n.e.c.), Hematological Disorders (non-oncologic), Pain), SDC: Urinary/Kidney Disorders, STA: Personalized & Precision Medicine