FACTORS ASSOCIATED WITH HEALTH-RELATED QUALITY OF LIFE AND HEALTH UTILITY VALUES AMONG COMMUNITY-BASED CANCER PATIENTS BASED ON THE QLQ-C30 AND QLU-C10D
Author(s)
Ting Zhou, PhD1, Jingxuan Chen, Master1, Hong-fei Hu, PhD1, Pei Wang, PhD2.
1China Pharmaceutical University, Nanjing, China, 2Fudan University, Shanghai, China.
1China Pharmaceutical University, Nanjing, China, 2Fudan University, Shanghai, China.
OBJECTIVES: Cancer patients frequently experience impaired health-related quality of life (HRQoL), yet evidence on HRQoL and health utility values (HUVs) among community-based cancer populations in China remains limited. This study aimed to assess HRQoL and HUVs across ten cancer system categories using the QLQ-C30 and QLU-C10D, and to explore associated sociodemographic and clinical factors.
METHODS: A cross-sectional survey was conducted among community-based cancer patients in Shanghai, China, during two periods: October to December 2017 and October 2018 to January 2019. The survey collected information on sociodemographic characteristics, cancer types, physical activity level (PAL), nutritional risk score (NRS), comorbidities, co-occurring symptoms, and HRQoL. HRQoL was assessed using the QLQ-C30, and cancer-specific HUVs were derived from QLQ-C30 responses using the QLU-C10D. Multiple linear regression and binary logistic regression analyses were performed to examine HRQoL, HUVs, and problematic item-level QLQ-C30 responses.
RESULTS: A total of 3,304 participants were included, with a mean age of 63.9 years and a mean QLU-C10D HUV of 0.87 (SD = 0.15). Older age, co-occurring symptoms, and elevated NRS were associated with poorer HRQoL outcomes, whereas higher PAL and monthly household income (MHI) were associated with better HRQoL outcomes. Patients with endocrine system cancers had the highest HUVs (0.94), whereas those with motor system cancers had the lowest HUVs (0.78). Among all examined factors, co-occurring symptoms were most strongly associated with problematic appetite-loss responses (OR = 6.32, 95% CI: 5.08-7.87), whereas higher PAL was associated with lower odds of impaired physical functioning (OR = 0.07, 95% CI: 0.02-0.23).
CONCLUSIONS: Multiple sociodemographic and clinical factors were significantly associated with HRQoL and HUVs among community-based cancer patients. Strategies targeting symptom management, nutritional support, physical activity promotion, and functional rehabilitation may help improve HRQoL and utility outcomes in community cancer care.
METHODS: A cross-sectional survey was conducted among community-based cancer patients in Shanghai, China, during two periods: October to December 2017 and October 2018 to January 2019. The survey collected information on sociodemographic characteristics, cancer types, physical activity level (PAL), nutritional risk score (NRS), comorbidities, co-occurring symptoms, and HRQoL. HRQoL was assessed using the QLQ-C30, and cancer-specific HUVs were derived from QLQ-C30 responses using the QLU-C10D. Multiple linear regression and binary logistic regression analyses were performed to examine HRQoL, HUVs, and problematic item-level QLQ-C30 responses.
RESULTS: A total of 3,304 participants were included, with a mean age of 63.9 years and a mean QLU-C10D HUV of 0.87 (SD = 0.15). Older age, co-occurring symptoms, and elevated NRS were associated with poorer HRQoL outcomes, whereas higher PAL and monthly household income (MHI) were associated with better HRQoL outcomes. Patients with endocrine system cancers had the highest HUVs (0.94), whereas those with motor system cancers had the lowest HUVs (0.78). Among all examined factors, co-occurring symptoms were most strongly associated with problematic appetite-loss responses (OR = 6.32, 95% CI: 5.08-7.87), whereas higher PAL was associated with lower odds of impaired physical functioning (OR = 0.07, 95% CI: 0.02-0.23).
CONCLUSIONS: Multiple sociodemographic and clinical factors were significantly associated with HRQoL and HUVs among community-based cancer patients. Strategies targeting symptom management, nutritional support, physical activity promotion, and functional rehabilitation may help improve HRQoL and utility outcomes in community cancer care.
Conference/Value in Health Info
2026-09, ISPOR Asia Pacific 2026, Bangkok, Thailand
Value in Health, Volume 55, Issue S1
Code
PCR7
Topic
Patient-Centered Research
Topic Subcategory
Patient-reported Outcomes & Quality of Life Outcomes
Disease
SDC: Oncology