Assessment of Health State Utilities Associated With Being a Caregiver for a Person With Alzheimer's Disease With Mild Cognitive Impairment or Dementia

Speaker(s)

Matza LS1, Howell TA1, Belger M2, Ritchie C3, Delio PR4, Johnston JA2, Tockhorn-Heidenreich A2
1Patient-Centered Research, Evidera, Bethesda, MD, USA, 2Eli Lilly and Company, Indianapolis, IN, USA, 3Scottish Brain Sciences, Edinburgh, and Professor of Brain Health and Neurodegenerative Medicine, University of St Andrews, St Andrews, Scotland, UK, 4Department of Neurology, Santa Barbara Cottage Hospital, Santa Barbara, CA, USA

Presentation Documents

OBJECTIVES: Caring for people living with Alzheimer’s disease (AD) with Mild Cognitive Impairment (MCI) and dementia has a significant impact on caregivers. The study purpose was to estimate health state utilities associated with being a caregiver for a person with MCI or dementia associated with AD.

METHODS: This vignette-based time trade-off (TTO) utility study was conducted with general population participants in the UK and US from 10/2023 to 02/2024. Vignettes were developed based on published literature, clinician interviews, and focus groups with caregivers of people with MCI/AD (recruited via Alzheimer’s Europe). Each participant valued six vignettes describing caregiver impact of having a relative (parent or spouse/partner) with AD of varying severity levels ranging from MCI to moderate dementia. Because there is no consensus regarding the upper anchor of the scale for caregiver utilities, four TTO approaches were explored in a pilot study (N=25) prior to the utility elicitation.

RESULTS: The sample included 304 participants in the UK (53.9% female; mean age = 46.7y) and 202 in the US (47.5% female; mean age = 46.4y). Based on a pilot study, the upper anchor of the utility scale was defined as absence of emotional and logistical caregiver burden (relative does not have MCI or dementia). In the UK sample, mean (SD) utilities representing care for a parent with MCI, mild dementia, and moderate dementia were 0.84 (0.18), 0.77 (0.20), and 0.62 (0.32). The health state utilities representing care for a spouse were 0.82 (0.18), 0.71 (0.25), and 0.54 (0.34). There were no significant differences in utilities between the UK and US.

CONCLUSIONS: Higher utilities were associated with less caregiving impact and responsibility. Methodological aspects of this study can inform future research on caregiver utility estimation. The resulting utilities may be useful for representing caregiver impact in cost-utility analyses of treatments for AD.

Code

PCR294

Topic

Patient-Centered Research

Topic Subcategory

Health State Utilities

Disease

Neurological Disorders, No Additional Disease & Conditions/Specialized Treatment Areas