Understanding the Burden of Sleep Disturbances and Vasomotor Symptoms on Work Productivity and Healthcare Resource Utilization Among Women Experiencing Menopause in the EU: A National Health and Wellness Study

Speaker(s)

Schoof N1, Nguyen J2, Modi K3, Drakeley S4, Yang L4, Banks VL5, Genga K6, Bolling KR2, Möller C7, Giannopoulou A8, Dinkel-Keuthage C7
1Bayer AG, Wiesbaden, HE, Germany, 2Bayer, Whippany, NJ, USA, 3Oracle Life Sciences, Austin, TX, USA, 4Oracle, Austin, TX, USA, 5Bayer, Reading, UK, 6Bayer, Sao Paulo, Brazil, 7Bayer AG, Berlin, Germany, 8Bayer, Basel, Switzerland

Presentation Documents

OBJECTIVES: Menopausal women frequently experience sleep disturbances (SD) and vasomotor symptoms (VMS), potentially affecting healthcare resource utilization (HCRU) and work productivity and activity impairment (WPAI). This study evaluated the burden on postmenopausal women, utilizing data from the NHWS.

METHODS: Women aged 40-65 with self-reported menopause were included. Post-menopause was defined as no menstrual bleeding for 12 months prior to survey completion. VMS were defined as self-reported hot flashes during daytime or nighttime (night sweats) in the past 12 months and SD as self-reported sleep difficulties in the past 12 months or select sleep-related symptoms weekly.

HCRU was based on the self-reported number of visits to a healthcare provider (HCP) in the past 6 months. The WPAI measures assessed among employed participants were absenteeism, presenteeism, and overall work productivity. Activity impairment was evaluated for all respondents. Higher percentage scores indicate increased impairment.

RESULTS: Among 14,908 postmenopausal women (mean age: 57.1, SD: 5.8), 44.0% self-reported VMS and 50.8% self-reported SD; 27.9% experienced both VMS and SD. 52.9% were employed.

Based on multivariable regression, the number of HCP visits was statistically significantly higher among women experiencing both symptoms (estimated marginal means (EMM): 5.5, p<0.001) compared to those experiencing neither (EMM: 4.3), followed by those with SD only (EMM:5.3, p<0.001), and then VMS only (EMM: 5.1, p<0.001).

Employed women experiencing both VMS and SD showed highest absenteeism and presenteeism compared to those experiencing neither (EMM: 6.6% vs. 4.9%, p=0.026, 17.4% vs. 12.9%, p<0.001, respectively). Similarly, work productivity and activity impairment was highest among the VMS with SD group compared to those experiencing neither (EMM: 18.8% vs.14.3%, p<0.001, 28.1% vs. 20.9%, p<0.001, respectively).

CONCLUSIONS: Women experiencing both VMS and SD reported highest HCRU and lowest work productivity compared to either VMS only, SD only, or neither, underscoring the impact of these symptoms combined on postmenopausal women.

Code

RWD122

Topic

Patient-Centered Research

Topic Subcategory

Patient-reported Outcomes & Quality of Life Outcomes

Disease

Reproductive & Sexual Health