Patient Preference Evidence in Health Technology Assessment: What Do We Really Know?

ISSUE: This session will evaluate what works in patient preference evidence (PPE) submissions for health technology assessment (HTA) and identify where current approaches are lacking. Overview: Despite continued proposals for incorporating PPE in HTA demonstrable impact remains limited. A 2020 ISPOR SIG report documented minimal use of health preference research in European reimbursement decisions. The session will start with an introduction to existing proposals for PPE in HTA (Hauber – 8 minutes). The session will then set out practical opportunities for PPE in HTA submissions focusing on key areas including evidence on the benefit-risk or benefit-burden trade offs that matter to patients; highlighting the value patients place on process of therapy; and settings in which existing methods fail to capture meaningful benefits that alternative preference methods might address (Meads – 14 minutes). The current evidence landscape on the use of PPE in HTA will be examined, contrasting successful PPE applications with problematic implementations. Notable successes will be discussed including the 2017 NICE daratumumab submission for multiple myeloma and PBAC consumer surplus demonstrations. These will be contrasted with applications that were poorly received and the reasons for this (Watson – 14 minutes). The session will then consider future directions for potential evidence integration, drawing on a series of collaborative workshops with HTA body representatives and their evaluations of hypothetical PPE case studies to identify practical pathways for meaningful implementation (Germeni – 14 minutes). The session will conclude with an interactive discussion featuring audience participation on potential barriers to developing fit-for-purpose PPE studies and exploring questions around different use cases where PPE might genuinely enhance HTA decision-making. This collaborative approach will help identify actionable solutions for bridging the gap between PPE theory and practice (10 minutes)