Association of Viral Infections in Alzheimer's Disease Among Patients With Mild Cognitive Impairment in Korea

Speaker(s)

Kim M1, Suh HS2
1College of Pharmacy, Kyung Hee University, Institute of Regulatory Innovation through Science, Kyung Hee University, College of Pharmacy, Pusan National University, Seoul, South Korea, 2College of Pharmacy, Kyung Hee University, Department of Regulatory Science, Graduate School, Kyung Hee University, Institute of Regulatory Innovation through Science, Kyung Hee University, Seoul, Korea, Republic of (South)

OBJECTIVES: The objective is to investigate the association between the history of infection disease and the occurrence of Alzheimer’s disease (AD) in patients with mild cognitive impairment (MCI) within a Korean population.

METHODS: We performed a retrospective cohort study from JUL 01/2019 to NOV 30/2022, utilizing the Health Insurance Review and Assessment database based on the Korean population. The study population included patients diagnosed with MCI from JUL 01/2022, to MAY 01/2022, and the index date was defined as the first date of diagnosis with MCI. Patients diagnosed with AD one year before the index date were excluded. The study population was subsequently divided into two groups: those who developed AD (AD group) and those who did not develop AD (non-AD group). The viral infectious diseases were herpes, zoster, and Helicobacter pylori within one year before the index date. The association between the history of infectious diseases and AD was measured by odds ratios (OR) and 95% confidence intervals using logistic regression. The model’s fitness was evaluated by c-statistics.

RESULTS: The study population (n=420,426) was divided into the AD group (15.3%, n=64,463) and the non-AD group (84.7%, n=355,963). Baseline characteristics differed significantly: the AD group had a mean age of 77.7±7.6 years (66.7% female), while the non-AD group had a mean age of 70.6±9.3 years (68.3% female) (p<0.001). A history of infection was not significantly associated with the occurrences of AD adjusting for age, sex, and comorbidities (OR for herpes, 0.74 [0.52-1.07]; OR for zoster, 0.90 [0.65-1.24]; OR for Helicobacter pylori, 0.53 [0.16-1.74]; c-statistics=0.732).

CONCLUSIONS: We found that a history of viral infectious diseases, including herpes, zoster, and Helicobacter pylori, was not significantly associated with AD in patients with MCI in the Korean population. Further research is warranted to explore other potential risk factors and the development of AD in individuals with MCI.

Code

CO113

Topic

Clinical Outcomes, Epidemiology & Public Health

Topic Subcategory

Comparative Effectiveness or Efficacy, Public Health

Disease

Geriatrics, Mental Health (including addition), Neurological Disorders