Societal Impact and Economic Burden of Lipodystrophy in Bulgaria

OBJECTIVES: Berardinelli-Seip congenital generalized lipodystrophy (CGL) is a rare disorder characterized by almost complete lipoatrophy, often leading to severe metabolic complications due to low leptin and elevated triglyceride levels. In Bulgaria, there are five confirmed CGL cases: three adult and two paediatric female patients. The annual direct cost of treating paediatric CGL patients is BGN 1,616,592.26, inclusive of diagnostic expenses. Data for the three adult patients' treatment costs are incomplete, but it is anticipated that the expense of managing complications in adults is higher, primarily due to the absence of leptin replacement therapy.

METHODS: Regarding the economic impact, two of the three working-age patients are unable to work due to their condition, resulting in an annual GDP loss of BGN 88,914.24 (BGN 44,451.35 per patient). Over their lifetimes, it is estimated that three out of the five patients will not contribute to the GDP, leading to a lifetime GDP loss of BGN 5,867,578.20 (BGN 1,955,859.40 per patient). For the two patients who are capable of working, the potential GDP loss due to premature death is also calculated, considering an average life expectancy of 40 years. This results in an additional GDP loss of BGN 1,955,859.40.

RESULTS: In summary, the total estimated GDP loss attributable to both working and non-working CGL patients over their lifetimes amounts to BGN 7,823,437.60. This analysis underscores the significant economic burden posed by CGL in Bulgaria, highlighting the need for effective treatment strategies and comprehensive support systems for affected individuals.

CONCLUSIONS: This analysis underscores the significant economic burden posed by CGL in Bulgaria, highlighting the need for effective treatment strategies and comprehensive support systems for affected individuals.