Hospitalization Burden of Crohn's Disease and Ulcerative Colitis in the Middle Atlantic: A Six-Cohort Analysis of Pooled National In-Patient Data (2016-2020)

Speaker(s)

Aggarwal S1, Kumar S2, Bela A1, Topaloglu J3
1NOVEL Health Strategies, Chevy Chase, MD, USA, 2NOVEL HEALTH STRATEGIES, COLUMBIA, MD, USA, 3Institute of Global Policy, Washington DC, DC, USA

OBJECTIVES: To assess the burden of hospitalizations due to Crohn’s Disease (CD) and Ulcerative Colitis (UC) in the Middle Atlantic region, using pooled national inpatient data from 2016 to 2020.

METHODS: The 2016-2020 National Inpatient Sample (NIS) datasets were pooled and analyzed for hospitalizations due to CD and UC in the Middle Atlantic region. Six cohorts were created: (1) all hospitalizations, (2) hospitalizations above the 90th percentile by charges, (3) hospitalizations below the 90th percentile by charges, (4) hospitalizations above the 90th percentile by comorbidity score, (5) hospitalizations below the 90th percentile by comorbidity score, and (6) in-hospital deaths. Comorbidity rates were assessed using the Charlson Index, the Elixhauser Method, and broad ICD-10 categories. Severe infections were evaluated based on a previously reported list of infections.

RESULTS: From 2016 to 2020, there were an estimated 247,160 CD and UC-related hospitalizations in the Middle Atlantic region. For the six cohorts, the mean ages were 53.56 (SD 20.49), 57.37 (SD 19.47), 53.14 (SD 20.56), 70.22 (SD 13.26), 52.42 (SD 20.4), and 70.03 (SD 14.48) years, respectively. The mean hospital length of stay (LOS) was 5.72 (SD 7.42), 17.49 (SD 16.61), 4.41 (SD 3.67), 9.05 (SD 10.33), 5.49 (SD 7.12), and 12.11 (SD 16.26) days, respectively. The mean total charges were $69,640 (SD 123,655), $292,967 (SD 297,883), $44,831 (SD 31,263), $109,990 (SD 147,589), $66,874 (SD 121,354), and $210,110 (SD 375,859), respectively. The comorbidity scores were 2.82 (SD 2.14), 4.01 (SD 2.23), 2.69 (SD 2.09), 7.64 (SD 0.9), 2.49 (SD 1.78), and 5.29 (SD 1.86), respectively. The rates of severe infections were 75%, 65%, 76%, 85%, 74%, and 79%, respectively.

CONCLUSIONS: Analyses of pooled five-year real-world hospital records of Crohn’s Disease and Ulcerative Colitis in the Middle Atlantic region show that these patients pose a significant clinical and economic burden.

Code

EE323

Topic

Economic Evaluation

Disease

Gastrointestinal Disorders