Hospitalization Burden of Congenital Adrenal Hyperplasia in New England: A Six-Cohort Analysis of National In-Patient Data (2016-2020)

Speaker(s)

Aggarwal S1, Kumar S2, Topaloglu O3
1NOVEL Health Strategies, Chevy Chase, MD, USA, 2NOVEL HEALTH STRATEGIES, COLUMBIA, MD, USA, 3NOVEL Health Strategies, Bethesda, MD, USA

OBJECTIVES: To assess the burden of hospitalizations due to Congenital Adrenal Hyperplasia (CAH) in New England using the pooled national inpatient database from 2016 to 2020.

METHODS: The 2016-2020 National Inpatient Sample (NIS) datasets were pooled and analyzed for hospitalizations due to CAH in New England. Six cohorts were designed: (1) all hospitalizations, (2) hospitalizations above the 90th percentile by charges, (3) hospitalizations below the 90th percentile by charges, (4) hospitalizations above the 90th percentile by comorbidity score, (5) hospitalizations below the 90th percentile by comorbidity score, and (6) in-hospital deaths. Comorbidity rates were assessed using three methods: the Charlson Index, the Elixhauser Method, and broad ICD-10 categories. Severe infections were assessed based on a previously reported list of infections.

RESULTS: From 2016 to 2020, there were an estimated 515 CAH-related hospitalizations in New England. For the six cohorts, the mean ages were 29.05 (SD 24.33), 32.5 (SD 28.88), 28.68 (SD 23.94), 65.5 (SD 12.98), 25.98 (SD 22.52), and 63.33 (SD 7.23) years, respectively. The mean hospital length of stay (LOS) was 7.65 (SD 18.45), 40.1 (SD 49.02), 4.16 (SD 3.92), 8.75 (SD 9.71), 7.56 (SD 19.03), and 13.33 (SD 15.31) days, respectively. The mean total charges were $69,913 (SD 206,773), $475,283 (SD 527,050), $26,325 (SD 21,114), $152,386 (SD 278,748), $62,968 (SD 199,949), and $300,199 (SD 456,407), respectively. The comorbidity scores were 1.69 (SD 1.89), 2.9 (SD 3.07), 1.56 (SD 1.7), 6.38 (SD 1.3), 1.29 (SD 1.32), and 6 (SD 1), respectively. The most common comorbid conditions were congestive heart failure, cardiac arrhythmias, hypothyroidism, renal failure, liver disease, obesity, diabetes, and depression.

CONCLUSIONS: Analyses of pooled five-year real-world hospital records of CAH in New England show that these patients pose a significant clinical and economic burden.

Code

EE321

Topic

Economic Evaluation

Disease

Diabetes/Endocrine/Metabolic Disorders (including obesity)