Comparison of the Measurement Properties of EQ-5D-Y-3L and CHU-9D Among Chinese High School Students with Myopia

Speaker(s)

Xie S1, Luo C1, Hong T2, Wang J3, Yang X3
1School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 12, China, 2School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada, 3Tianjin Eye Hospital, Tianjin, Tianjin, China

Presentation Documents

OBJECTIVES: To evaluate and compare the measurement properties of the EQ-5D-Y-3L and CHU-9D among Chinese high school students with myopia.

METHODS: Adolescents with myopia were recruited from three high schools in Tianjin, China. Social-demographic characteristics, self-reported EQ-5D-Y-3L, CHU-9D and VFQ-25 responses were collected through the online survey. The agreement was assessed using intraclass correlation coefficients (ICC) and paired Wilcoxon signed-rank test. Convergent validity was examined using Spearman's rank correlation. Known-group validity and discriminate validity were assessed using the effect sizes among different subgroups divided by degree of myopia and VFQ-25 scores, respectively. Sensitivity was compared using relative efficiency.

RESULTS: A total of 1,428 respondents (50.5% male, mean age 17.0 years, 72.0% low-myopia, 23.3% high-myopia) were included in this study. A higher ceiling effect was observed in EQ-5D-Y-3L than in CHU-9D (67.6% vs. 21.1%). The mean (SD) utility was 0.953 (0.065) for EQ-5D-Y-3L and 0.832 (0.163) for CHU-9D. The ICC of the total sample was 0.313 (p < 0.001) and p value of paired Wilcoxon signed-rank test was less than 0.001. The Spearman's rank correlation (range: 0.062-0.584) indicated an acceptable convergent validity between the dimensions of EQ-5D-Y-3L and CHU-9D. The known-group validity and the discriminate validity of EQ-5D-Y-3L was basically equivalent with CHU-9D (ES: -0.108 vs. -0.323, 0.754 vs. 0.949). The relative efficiency of CHU-9D with respect to EQ-5D-Y-3L was 0.52 at distinguishing between respondents with different degree of myopia.

CONCLUSIONS: Both the EQ-5D-Y-3L and CHU-9D showed comparable validity when using among adolescents with myopia in China. The EQ-5D-Y-3L showed higher sensitivity than CHU-9D. The two measures may not be interchangeable given the systematic difference in utility values between the EQ-5D-Y-3L and CHU-9D. More research is needed to compare the reliability and responsiveness.

Code

PCR206

Topic

Patient-Centered Research

Topic Subcategory

Instrument Development, Validation, & Translation

Disease

Sensory System Disorders (Ear, Eye, Dental, Skin)