Burden of Cardiovascular Disease Among Women Breast Cancer Patients in Inner Mongolia, China

Speaker(s)

ABSTRACT WITHDRAWN

OBJECTIVES:

Growing attention has been paid to the cardio-toxicities in cancer treatments. Breast cancer (BC), as the most prevalent malignant tumors in women, have over 80% five-year survival rate and shared many risk factors with cardiovascular disease (CVD). This study intends to describe the CVD burden among women BC patients in Inner Mongolia, a minority autonomous region in China.

METHODS:

This retrospective cohort study was conducted based on the Inner Mongolia Regional Health Information Platform during 2012-2021. BC patients were identified using diagnosis characters and ICD-10 code, and followed-up ever since, till new-onset CVD, death, or March 2021. New-onset CVD was documented by hospitalization, outpatient or medication records, and categorized into 12 subtypes. The incidence density and cost were calculated.

RESULTS:

In 29516 BC patients included, the mean age was 52.03±11.02, 16.55% were Mongolian. After 3.59±2.34 years follow-up, we documented 12527 (42.44%) new-onset CVD cases. The incidence density of new-onset CVD was 1844.41 per million person-years (95% CI: 1812.25-1877.00). Further differentiating CVD subtypes, hypertension (972.63, 949.32-996.38 per million person-years), arrhythmia (798.01, 776.91-819.55), coronary artery disease (CAD, 539.03, 521.71-556.78), cerebrovascular disease (266.94, 254.80-279.51), peripheral vascular disease (90.55, 83.53-98.00), and heart failure (HF, 58.45, 52.84-64.05) contributed to the top six incidence densities. Those who received BC therapy (4585.25, 4490.27-4681.74) have higher CVD incidence density than those didn’t (3597.29, 3481.78-3715.67, P<0.001). No discrepancy was observed across ethnicity (Mongolian 4120.78, 3918.10-4331.22 vs Han 4267.39, 4186.20-4349.76, P=0.521) and GDP level of residence (lower GDP level 4278.76, 4174.70-4384.76 vs higher 4208.39, 4103.53-4315.25, P=0.437). The estimated average annual direct medical costs per patient was 18259.90 CNY (7256.46, 38932.42) for hospitalization, 2330.28 CNY (968.55, 6320.21) for outpatient.

CONCLUSIONS:

This study, with large sample-size, revealed the CVD burden of Inner Mongolia BC patients by subtypes. Results suggested that more cardio-protective strategies should be prompted for BC patients, especially for hypertension, arrhythmia, and CAD.

Code

EPH180

Topic

Economic Evaluation, Epidemiology & Public Health, Health Policy & Regulatory, Study Approaches

Topic Subcategory

Electronic Medical & Health Records, Health Disparities & Equity

Disease

Cardiovascular Disorders (including MI, Stroke, Circulatory), No Additional Disease & Conditions/Specialized Treatment Areas, Oncology