Breaking a Vicious Cycle: Including the Patient Perspective for Meaningful Psoriasis Severity Evaluation Towards Broader Recognition of Burden and Unmet Needs

Speaker(s)

Subiron-Naidoo N1, Lee L2, Annunziata K2, Stankus A2
1Oracle Life Sciences, Le Perreux-sur-Marne, 94, France, 2Oracle Life Sciences, Austin, TX, USA

Presentation Documents

OBJECTIVES: Patient-perceived psoriasis severity may not correlate with clinical severity classification. This study examined humanistic and economic burdens of patients with psoriasis severity classified as mild according to body surface area (BSA). Among whom, those who self-reported their (SR) severity as moderate-to-severe (SR-ModSev) were compared with those who self-reported their severity as mild (SR-Mild).

METHODS: This analysis used 2019 US National Health and Wellness Survey data , an internet-based cross-sectional survey of adults.

Socio-demographic, clinical, and patient-reported outcome (PRO) data between SR-ModSev and SR-Mild groups were compared using chi-square and ANOVA tests. PROs included the Short Form (SF)-36v2, Work Productivity and Activity Impairment Questionnaire (WPAI), Patient Health Questionnaire (PHQ)-9 Scale and Generalized Anxiety Disorder (GAD)-7 Scale.

RESULTS: Across both groups (SR-ModSev: n= 516, SR-Mild: n=1864), sex was similarly distributed. Patients in the SR-ModSev group were younger (54.2% vs 40% in age bracket 18-44, p<0.001).

SR-ModSev group had worse SF36v2 mental health (40.6 vs 45.6, p<0.001) and physical composite scores (44.8 vs 48.9, p<0.001).

SR-ModSev showed greater absenteeism (20.3% vs 9.65%, p<0.001), work productivity loss (47% vs 27.6%, p<0.001), and activity impairment (43.7% vs 28%, p<0.001).

A greater proportion of SR-ModSev had severe depression and generalized anxiety (PHQ9 13.3% vs 5.1%, p<0.001; GAD-7 16.6% vs 7.2%, p<0.001).

SR-ModSev had a higher proportion of dermatologist visits (23.4% vs 16.8%, p<0.001), emergency room visits (30.8% vs 17.4%, p<0.001) and hospitalizations (25% vs. 11.3%, p<0.001).

CONCLUSIONS: Despite both groups’ psoriasis severity being clinically classified as mild using BSA, the SR-ModSev group had higher burden: worse quality of life, greater work productivity and activity impairment, greater severe depression, and generalized anxiety, and incurred higher healthcare resource utilization compared with SR-Mild.

Excluding patient’s perspectives in psoriasis severity evaluation leads to under-recognition of poor health outcomes and important burden, perpetuating a vicious cycle of unmet needs and disease progression.

Code

PCR147

Topic

Clinical Outcomes, Patient-Centered Research

Topic Subcategory

Clinical Outcomes Assessment, Patient Engagement, Patient-reported Outcomes & Quality of Life Outcomes

Disease

Sensory System Disorders (Ear, Eye, Dental, Skin), Systemic Disorders/Conditions (Anesthesia, Auto-Immune Disorders (n.e.c.), Hematological Disorders (non-oncologic), Pain)