Cost-Effectiveness Analyses of Continuous Renal Replacement Therapy (CRRT) System in Health Care System in LMIC/LATAM/Brazil

OBJECTIVES: The CRRT System is designed to provide individualized care for critically ill patients in the intensive care unit (ICU) through the CRRT’s administration and support therapies. We analyse the cost-effectiveness of CRRT system in LMIC/LATAM/BRAZIL Health Care.

METHODS: Publications of hospital cases have reported that 4 % to 20 % of all hospitalized patients and up to 50% of those admitted to an Intensive Care Unit (ICU) developed Renal Injuries( RI ) . 35% of critically ill patients who are admitted to the ICU have some degree of RI and up to 7 % of these will require of renal replacement therapy ( RRT) . In 2022, there were a total of 7,190 hospitals operating in Brazil, approximately 36,000 ICU beds. It means a Brazilian data cluster of > 2000 patients/ year needs RRT (~ 2000 x 5 y = 10000 ) . This study checked the CHEERS (Consolidated Health Economic Evaluation Reporting Standards) standard for reporting economic evaluation cited.

RESULTS: Assuming that , results for a 5-year time horizon, clinical outcomes (QALYS) are 0.954 for CRRT vs. 0.964 for IRRT (Intermittent), i.e., an increment of 0.0107. The total cost per patient was R$ 30,650 for CRRT vs. R$ 32,333 for IRRT, a saving of > R$ 1,683 per patient. In one year ~ 2000 X ~ R $ 2,000 = ~ more than R $ 4.000 000 of savings , which cumulatively we would have in 5 years, more than R$ 20 million ( 4 MILLION USD ) of saving, plus QALY increment.

CONCLUSIONS: Studies, like the cohort of patients initially treated with CRRT have better clinical outcomes (QALYs ) and lower total treatment costs and high savings and avoidance . Patients treated with CRRT are more likely to regain renal function, by Markov data. Further validation in other datasets is advisable.