OBJECTIVES: To clarify the real-world trends and treatment duration of patients with 1stand 2nd stage syphilis using integrated data of IQVIA Claims, JAST and DeSC database.

METHODS: Patients with syphilis (ICD-10: A51, A52) and corresponding treatment who have 6 months follow-up and 6 months look-back period in the IQVIA Claims, JAST and the DeSC database were identified. IQVIA Claims and JAST database contains the payer claims data of the health insurance union for Japanese workers. The DeSC database contains national health insurance (provided for individuals below 75 years of age who are not covered by other public health insurance); and later-stage elderly healthcare system (provided for individuals over 75 years old). The data period was between April 2015 and June 2022. Patients’ demographics, treatment duration, and HCRU were described.

RESULTS: Of 440 patients with definitive diagnosis of syphilis who received syphilis treatment (Amoxicillin, Benzylpenicillin, Spiramycin, Minocycline), 342 (77.7%) patients were male, and 98 (22.3%) patients were female. Mean(SD) age for male and female was 42(12.5) and 35.4(15.2), respectively, whereas the median(1st quantiles, 3rd quantiles) was 41(32, 51) and 31(24, 43), respectively. The majority of patients were treated with oral penicillin. Mean treatment duration was 38.2 days in all patients and 38.8 days in 1st stage syphilis patients, whereas the median was 28 days and 29 days, respectively.

CONCLUSIONS: The majority of patients with syphilis was male in our study, which is consistent with the reported cases by WHO (2022). The patients in our study were slightly older compared to the report by WHO, who were in the late 20s in the US. To our knowledge, this is the first time report about the treatment, frequency of test and HCRU for patients with syphilis in Japan real-world setting. Further details will be discussed in the poster.

ISPOR 2023

May 7-10, 2023

Posters

Clinical Outcomes

Biologics & Biosimilars

Cardiovascular Disorders (including MI, Stroke, Circulatory)

Diabetes/Endocrine/Metabolic Disorders (including obesity)

Drugs

Geriatrics

Infectious Disease (non-vaccine)

Mental Health (including addition)

Musculoskeletal Disorders (Arthritis, Bone Disorders, Osteoporosis, Other Musculoskeletal)

Neurological Disorders

No Additional Disease & Conditions/Specialized Treatment Areas

Oncology

Pediatrics

Rare & Orphan Diseases

Respiratory-Related Disorders (Allergy, Asthma, Smoking, Other Respiratory)

Sensory System Disorders (Ear, Eye, Dental, Skin)

Surgery

Urinary/Kidney Disorders

Vaccines

Economic Evaluation

Biologics & Biosimilars

Cardiovascular Disorders (including MI, Stroke, Circulatory)

Diabetes/Endocrine/Metabolic Disorders (including obesity)

Drugs

Gastrointestinal Disorders

Generics

Genetic, Regenerative & Curative Therapies

Geriatrics

Infectious Disease (non-vaccine)

Injury & Trauma

Medical Devices

Mental Health (including addition)

Musculoskeletal Disorders (Arthritis, Bone Disorders, Osteoporosis, Other Musculoskeletal)

Neurological Disorders

No Additional Disease & Conditions/Specialized Treatment Areas

Oncology

Pediatrics

Personalized & Precision Medicine

Rare & Orphan Diseases

Reproductive & Sexual Health

Respiratory-Related Disorders (Allergy, Asthma, Smoking, Other Respiratory)

SDC: Diabetes/Endocrine/Metabolic Disorders (including obesity)

SDC: Oncology

Sensory System Disorders (Ear, Eye, Dental, Skin)

Surgery

Systemic Disorders/Conditions (Anesthesia, Auto-Immune Disorders (n.e.c.), Hematological Disorders (non-oncologic), Pain)

Urinary/Kidney Disorders

Epidemiology & Public Health

Alternative Medicine

Cardiovascular Disorders (including MI, Stroke, Circulatory)

Diabetes/Endocrine/Metabolic Disorders (including obesity)

Drugs

Gastrointestinal Disorders

Generics

Geriatrics

Infectious Disease (non-vaccine)

Mental Health (including addition)

Musculoskeletal Disorders (Arthritis, Bone Disorders, Osteoporosis, Other Musculoskeletal)

Neurological Disorders

No Additional Disease & Conditions/Specialized Treatment Areas

Oncology

Reproductive & Sexual Health

Respiratory-Related Disorders (Allergy, Asthma, Smoking, Other Respiratory)

Sensory System Disorders (Ear, Eye, Dental, Skin)

Surgery

Systemic Disorders/Conditions (Anesthesia, Auto-Immune Disorders (n.e.c.), Hematological Disorders (non-oncologic), Pain)

Vaccines

Health Policy & Regulatory

Biologics & Biosimilars

Cardiovascular Disorders (including MI, Stroke, Circulatory)

Drugs

Mental Health (including addition)

Neurological Disorders

No Additional Disease & Conditions/Specialized Treatment Areas

Oncology

Pediatrics

Respiratory-Related Disorders (Allergy, Asthma, Smoking, Other Respiratory)