Clinical Effectiveness Innovative Insulin Delivery Devices Compared with Conventional Therapy for Patients with Diabetes Mellitus: A Systematic Review and Meta Analysis

OBJECTIVES: Diabetes mellitus is a chronic metabolic disease defined by persistently elevated blood glucose levels. Patients with type 1 Diabetes mellitus are considered in the review. Type 1 diabetes is characterized by destruction of pancreatic beta cells, typically secondary to an autoimmune process. Hence, to evaluate the clinical effectiveness of innovative insulin delivery device- insulin pen compared with conventional therapy for patients with type 1 Diabetes mellitus.

METHODS: A comprehensive search was performed at various electronic databases using PubMed, Web of Science, Google Scholar, and Cochrane. A PRISMA method is used to curate and collocate the studies. Quantitative data were pooled into statistical meta-analyses using the Cochrane Review Manager (RevMan) to compare clinical efficacy innovative insulin delivery device -insulin pens versus conventional therapy.

RESULTS: A total of 3123 articles were obtained and after evaluation, 26 articles were accepted that answered the research questions and met the criteria for systematic review and meta-analysis. Therefore, the outcomes for the metanalysis with mean difference HbA1, (-0.62, 95% CI: -0.85, -0.40) and risk ratio for diabetic ketoacidosis (DKA) (1.29, 95% confidence interval 0.62 to 2.69) and severe hypoglycemia (0.79, 95% confidence interval 0.67 to 0.94) we found that moderate evidence for innovative delivery device-insulin pen slightly decreased HbA1c, DKA, and severe hypoglycemia compared with conventional therapy.

CONCLUSIONS: In this review we found that Innovative insulin delivery device -Insulin pens played an important role in patients’ recovery and decreased HbA1c, DKA, and severe hypoglycemia. Potential use of pen injectors improves glycemic control in type 1 diabetes compared with conventional therapy. This adds to the confidence that innovative delivery device-insulin pen will become more prevalent in the next few years.