The Impact of Administration Modality on Quality of Life for Respiratory Diseases in Japan Based on Patient-Reported Outcomes

OBJECTIVES:

Recently, triple combination therapy of inhaled corticosteroid (ICS), long-acting β-agonists (LABA) and long-acting muscarinic antagonist (LAMA) has become available for chronic obstructive pulmonary disease (COPD) and asthma in Japan. This could simplify treatment management and may have an impact on outcomes. This study aimed to examine the impact of administration modality on outcomes in terms of HRQoL.

METHODS:

Data from the 2021 Patient Mindscape® study was used to examine the impact of administration modality on HRQoL among COPD and/or asthma patients in Japan administered triple therapy (TT) – including fixed-dose combination triple therapy of ICS, LABA, and LAMA (FDTT) or a non-fixed dose combination regimen (non-FDTT). Patient Mindscape® is a nationwide patient survey conducted annually in Japan among 500,000+ patients undergoing drug treatment for 80+ conditions. Patients that reported a COPD and/or asthma diagnosis and continuous TT administration were included. HRQoL was estimated using EQ-5D-5L responses. The following definition was applied to categorize administration modality; fixed-dose combination TT (“FDTT”) and those who TT regimen included a monotherapy (“non-FDTT”).

RESULTS:

Among 10,734 patients, 538 were administered TT including 124 COPD patients, 360 asthma patients and 54 asthma and COPD overlap (ACO) patients. Mean HRQoL among COPD patients overall was 0.811, with 0.808 for FDTT (n=108), 0.832 for non-FDTT (n=16). Mean HRQoL among asthma patients was 0.849 overall, with 0.864 for FDTT (n=214) and 0.826 for non-FDTT (n=146). Mean HRQoL among ACO patients was 0.819 overall, with 0.842 for FDTT (n=29) and 0.792 for non-FDTT (n=25).

CONCLUSIONS:

While a positive impact of FDTT on HRQoL was found for asthma and ACO patients, no such trend was observed for COPD. Although the number of each population by administration modality was limited, administration modality may be an important consideration for treatment outcomes.