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Targeted Literature Review of Caregiver Burden and Generational Burden in Depression

Speaker(s)

Ferries E1, Chitnis A2, Vera T3, Suthoff E3
1Sage Therapeutics, Inc., Parker, CO, USA, 2Biogen Inc., Cambridge, MA, USA, 3Sage Therapeutics, Inc., Cambridge, MA, USA

OBJECTIVES: As of 2020, the global prevalence of depression was approximately 246 million individuals; depression contributes substantially to the clinical, economic, and humanistic global burden of disease. The humanistic burden often includes impaired interpersonal relationships, decreased quality of life, and increased suicide risk. However, the burden extends beyond the patient with depression. Due to severe, long-lasting symptoms, depression can have a significant impact on caregivers and families and its presence in the progeny of afflicted parents can result in generational burden.

This targeted literature review examined the caregiver burden and generational impact of depression.

METHODS: The Embase and MEDLINE databases were searched for publications from January 2017 to April 1, 2022, using the Ovid platform. Abstracts published in conference proceedings were searched from January 1, 2020 to April 1, 2022.

RESULTS: A total of 42 studies (including 9 on caregiver burden and 33 on generational burden) from 25 countries were included in the review. There was vast heterogeneity in methods across studies; however, the literature consistently demonstrated caregivers of patients with depression experienced greater burden than non-caregivers. Caregivers of patients with depression reported lower health-related quality of life, greater work and activity impairment and a greater proportion had more depressive symptoms compared to non-caregivers and other chronic-disease caregivers. The prevalence of depression in caregivers ranged from 28.5%−84.6%.

Most studies evaluating generational burden (N=29, 88%) found a significant relationship between parental and offspring depression (odds ratio, OR: 1.3-3.0]. Both maternal (OR: 1.33−2.8) and paternal depression (OR: 1.07−1.9) was generally associated with depressive symptoms in offspring.

CONCLUSIONS: Evidence suggests depression is associated with increased caregiver burden and increased likelihood of depression among offspring of individuals with depression. Disrupting the disease trajectory of depression with early, effective treatment may reduce burden of disease and the societal impact beyond just the patient.

Code

PCR254

Topic

Patient-Centered Research

Topic Subcategory

Patient-reported Outcomes & Quality of Life Outcomes

Disease

No Additional Disease & Conditions/Specialized Treatment Areas