Influence of Nutritional State and the Phase Angle in the Health Related Quality of Life and Clinical Outcome in Head and Neck Cancer

Speaker(s)

Sat-Muñoz D1, Gutiérrez-Rodríguez LX2, Martínez-Herrera B3, González Rodríguez J4, Trujillo-Hernández B5, Quiroga-Morales LA6, Alcaráz-Wong AA7, Dávalos-Cobian C7, Solórzano-Meléndez A8, Flores-Carlos JD9, Rubio Jurado B8, Salazar-Páramo M10, Gómez-Sánchez E11, Carrillo-Nuñez GG10, Nava-Zavala AH12, Balderas-Peña LMA13
1Universidad de Guadalajara. Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco, JAL, Mexico, 2Universidad de Guadalajara. Centro Universitario del Sur, Ciudad Guzmán, JA, Mexico, 3Hospital General de Zona No. 2 "Dr. Francisco Padrón Puyou", Colima, Mexico, 4Universidad de Guadalajara. Centro Universitario de Ciencias de la Salud, Zapopan, JAL, Mexico, 5Universidad de Colima, Colima, JA, Mexico, 6Universidad Autónoma de Guadalajara, Zapopan, JA, Mexico, 7Instituto Mexicano del Seguro Social. UMAE Hospital de Especialidades. Centro Médico Nacional de Occidente, Guadalajara, JA, Mexico, 8UMAE Hospital de Especialidades Centro Médico Nacional de Occidente IMSS, Guadalajara, Jalisco, JA, Mexico, 9UMAE Hospital de Especialidades Centro Médico Nacional de Occidente., Guadalajara, Jalisco, JA, Mexico, 10Universidad de Guadalajara. Centro Universitario de Ciencias de la Salud, Guadalajara, JA, Mexico, 11Universidad de Guadalajara. Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco, Mexico, 12Instituto Mexicano del Seguro Social, Órgano de Operación Administrativa Desconcentrada Jalisco, Guadalajara, JA, Mexico, 13Universidad de Guadalajara. Centro Universitario de Ciencias de la Salud, Guadalajara, JAL, Mexico

Presentation Documents

INTRODUCTION: In patients with head and neck cancer malnutrition is common. Most cases are treated by chemo-radiotherapy and surgery with adverse effects in the aerodigestive area. Health-related quality of life, clinical and biochemical characteristics, survival and risk of death were studied.

OBJECTIVES: This report aims to determine the role of phase angle in the outcomes of head and neck cancer patients in a population with a high prevalence of overweight and obesity.

METHODS: The selected subjects were divided into normal and low phase angle (PA) groups. The subjects also divided into sarcopenia/sarcopenic obesity phenotyp and without sarcopenia. They were follow up for at least two years. The EORTC validated questionnaires for Mexican Spanish QLC-C30 and H&N35 were used to assess health-related quality of life.

RESULTS: Mean ages were 67.2 and 59.3 for low and normal PA, respectively. Patients with PA <4.42° had significant differences in age, anthropometric and biochemical indicators of malnutrition and inflammatory status compared to patients with PA>4.42º. Statistical differences were found in the functional and symptom scales, with lower functional scores and higher symptom scores in patients with low PA. Median survival was 19.8 months for those with PA <4.42° versus 34.4 months for those with PA >4.42° (p<0.001).The relative risk of death is related to low PA, sarcopenia, or sarcopenic obesity (2.6; p<0.001). The percentage of living patients (41.7%) is almost the same percentage of deceased subjects (43.1%; p=0.002), with high death rates in patients with PA <4.42º.

CONCLUSIONS: Phase angle was the most crucial predictor of survival and a risk factor for death in the studied cases.

Code

PCR87

Topic

Clinical Outcomes, Patient-Centered Research

Topic Subcategory

Clinician Reported Outcomes, Patient-reported Outcomes & Quality of Life Outcomes, Relating Intermediate to Long-term Outcomes

Disease

SDC: Musculoskeletal Disorders (Arthritis, Bone Disorders, Osteoporosis, Other Musculoskeletal), SDC: Oncology, STA: Nutrition, STA: Surgery