Program

In-person AND virtual! – We are pioneering a new conference format that will connect in-person and virtual audiences to create a unique experience. Matching the innovation that comes through our members’ work, ISPOR is pushing the boundaries of innovation to design an event that works in today’s quickly changing environment. 

In-person registration included the full virtual experience, and virtual-only attendees will be able to tune into live in-person sessions and/or watch captured in-person sessions on-demand in addition to having a variety of virtual-only sessions to attend.

Efficacy and Safety of Flavonoids in Adults with Hemorrhoidal Disease: A Systematic Review

Speaker(s)

Cázarez-Huazano S1, Cortes- Sanabría L2, Cruz CA3, Guzmán Vázquez S4, Martinez Samano E5, Soto H4, Escobar Y5
1PEMEX, Mexico City, EM, Mexico, 2Mexican Social Security Institute, Jalisco, JA, Mexico, 3National Health Council, Mexico City, DF, Mexico, 4Agencia Mexicana de Evaluación de Tecnologías Sanitarias AC, Iztapalapa, Mexico, 5Mexican Agency of Sanitary Technology Evaluation, Mexico DF, EM, Mexico

Objective: A systematic review of the literature on the efficacy and safety of flavonoids versus other available treatments in adults with hemorrhoidal disease with or without surgery.

Methods: We performed searches on the main published studies and study protocols databases to identify randomized clinical trials, systematic reviews or meta-analysis assessing the efficacy and safety of flavonoids versus currently available treatments in patients with hemorrhoidal disease with or without surgery. The selection, data extraction, bias risk and study quality evaluations was performed by at least 2 researchers based on Cochrane methodology and the PRISMA checklist.

Results: Seven studies were selected. Based on high quality evidence, reports of bleeding decreasing in 42/66 patients on the flavonoids group and in 29/68 of the placebo group was statistically significant (Chi-Square = 5.9; p = 0.015). Three meta-analyses of studies with placebo as a comparator were analyzed, flavonoids improved bleeding cessation with no significant difference on pain improvement or adverse events between groups.

Conclusions: The qualitative and quantitative analysis showed that flavonoids can improve the main symptoms in adults with hemorrhoidal disease with or without surgery. However, more studies are required to conclude on the efficacy and safety in comparison with other treatments.

Code

CO140

Topic

Clinical Outcomes

Topic Subcategory

Comparative Effectiveness or Efficacy

Disease

Gastrointestinal Disorders