Program

In-person AND virtual! – We are pioneering a new conference format that will connect in-person and virtual audiences to create a unique experience. Matching the innovation that comes through our members’ work, ISPOR is pushing the boundaries of innovation to design an event that works in today’s quickly changing environment. 

In-person registration included the full virtual experience, and virtual-only attendees will be able to tune into live in-person sessions and/or watch captured in-person sessions on-demand in addition to having a variety of virtual-only sessions to attend.

Assessing the Relationship between Heart Disease and Related Comorbidities with Dementia and Alzheimer's Disease

Speaker(s)

Denisenko D, Spotts H, Ekong G
Western New England University, Springfield, MA, USA

Presentation Documents

Objectives: Although both heart disease (including heart failure, myocardial infarction, and coronary and peripheral artery diseases) and depression are associated with increased dementia risk, little research has been published evaluating the relationship between these conditions and dementia or Alzheimer’s disease (AD). The objective of this study was to explore the association between having both these comorbidities and developing dementia or AD.

Methods: This retrospective study analyzed electronic medical records database (Private Source 42) provided by HealthVerity Marketplace. Patients were required to have a diagnosis in an inpatient/outpatient setting between January 1, 2014 and June 30, 2019. Patients had at least 3 years of continuous enrollment. The participants characteristics were documented and the likelihood of developing dementia or AD was analyzed using adjusted models for logistic regression.

Results: There were 49,735 patients included in the analysis (age: 69.4±11.1 years; 52.7% male). At the study baseline, 13,294 (26.7%) had heart disease; 2,978 (6.7%) had depression; 1277 (2.6%) had both heart disease and depression. Analysis revealed that patients with heart disease or depression had a greater risk of developing dementia including Alzheimer’s disease and vascular dementia. Patients with both heart disease and depression were more likely to develop dementia (OR 3.47, 95% CI 2.76-4.36) and AD (OR 3.23, CI 1.93-5.41) compared to patients with only heart disease (OR 1.87, CI 1.65-2.12). These patients were also more likely to develop vascular dementia (OR 5.51, CI 3.04-10). Patients with depression were almost four times more likely to have dementia (OR 3.95, CI 3.37-4.62).

Conclusions: Our study showed that having both heart disease and depression was associated with higher odds of developing dementia and AD. Findings are important due to the high prevalence of dementia and AD. Therefore, early diagnosis and treatment of these comorbidities is vital to reduce the burden of dementia and AD.

Code

EPH145

Topic

Epidemiology & Public Health, Real World Data & Information Systems, Study Approaches

Topic Subcategory

Electronic Medical & Health Records, Health & Insurance Records Systems, Public Health

Disease

Cardiovascular Disorders, Mental Health