Short Communication from the Co-Editors-in-Chief
From the Co-Editors-in-Chief
Michael Drummond, C. Daniel Mullins
Cost-Effectiveness and Clinical Practice Guidelines: Have We Reached a Tipping Point?
Cost-Effectiveness and Clinical Practice Guidelines: Have We Reached a Tipping Point?—An Overview
Louis P. Garrison, Jr.
Developments suggest that the application of cost-effectiveness analysis for health care decision making in the US is evolving—and may be approaching a tipping point. With increasing pressures on drug prices, perhaps reflecting challenges to industry sustainability, payers, providers, and patients are looking for value for money.
Considering Cost-Effectiveness in Cardiology Clinical Guidelines: Progress and Prospects
Mark A. Hlatky, MD
Challenges in Measuring Cost and Value in Oncology: Making It Personal
Peter P. Yu, MD, FACP, FASCO
Clinical Guidelines: A NICE Way to Introduce Cost-Effectiveness Considerations?
Michael Drummond PhD
Breakthrough Cancer Pain: Ten Commandments
Sebastiano Mercadante, Arturo Cuomo
This commentary provides the golden rules, namely the “Ten Commandments”, for a correct diagnostic pathway of breakthrough cancer pain a consequent personalized pharmacological treatment.
Cost-Utility Analysis of Long-Acting Beta Agonists versus Leukotriene Receptor Antagonists in Older Adults with Persistent Asthma Receiving Concomitant Inhaled Corticosteroid Therapy
Shoroq Altawalbeh, Joshua M Thorpe, Carolyn T Thorpe, Kenneth J Smith
This article by Shoroq Altawalbeh et al. evaluates the cost-utility of ICS+LABA compared with ICS+LTRA in older adults with asthma.
Performance and Validation of Chronic Liver Disease Questionnaire-Hepatitis C Version (CLDQ-HCV) in Clinical Trials of Patients with Chronic Hepatitis C
Zobair Younossi, Maria Stepanova, Linda Henry
This article systematically validates a hepatitis C-specific health-related quality-of-life instrument, chronic liver disease questionnaire-HCV, in patients with chronic hepatitis C.
Health or Happiness? A Note on Trading Off Health and Happiness in Rationing Decisions
E.J. van de Wetering, Job van Exel, Werner Brouwer
In this study, the authors find that nearly half of the respondents were willing to discriminate between patient groups based on their health and happiness levels before and after treatment.
Comparative Effectiveness Research/Health Technology Assessment
On the Estimation of the Cost-Effectiveness Threshold: Why, What, How?
Laura Vallejo-Torres, Borja García-Lorenzo, Iván Castilla, Cristina Valcárcel-Nazco, Lidia García-Pérez, Renata Linertová, Elena Polentinos-Castro, Pedro G Serrano-Aguilar
This article provides an in-depth discussion of different conceptual views and undertake a systematic review of empirical analyses on health care systems.
Health Policy Analysis
A Tale of Two Thresholds: A Framework for Prioritization within the Cancer Drugs Fund
Paul Granby, Simon Leigh
The objective in this article was to estimate cancer drugs fund willingness (CDF) and ability-to-pay for cancer drugs, providing guidance regarding where CDF funds are best spent, and determining the number of NHS quality-adjusted life years displaced through the existence of the fund.
Health Technology Assessment for Molecular Diagnostics: Practices, Challenges and Recommendations from the Medical Devices and Diagnostic Special Interest Group
Susan Garfield, Julie Polisena, Daryl Spinner, Anne Postulka, Christine Y Lu, Simrandeep K Tiwana, Eric Faulkner, Nick Poulios, Vladimir Zah, Michael Longacre, Michael Pollock
The ISPOR Devices and Diagnostic Special Interest Group reviewed diagnostic specific HTA programs and identified elements representing common and best practices
A Framework for Developing the Structure of Public Health Economic Models
Hazel Squires, James Chilcott, Ronald Akehurst, Jennifer Burr, Michael P Kelly
This article presents a framework informed by literature reviews of the key challenges in public health economic modelling and existing conceptual modelling frameworks; qualitative research to understand the experiences of modelers when developing public health economic models; and piloting a draft version of the framework.
Estimating the Medical Care Costs of Obesity in the US: Systematic Review, Meta-Analysis and Empirical Analysis
David D Kim, Anirban Basu
This article provides a systematic review and a meta-analysis of the twelve recently published articles that reported the medical care costs associated with obesity. The authors performed an original analysis to understand the impact of study methodology on the magnitude of the magnitude of the cost of obesity.
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