Reproducibility and Clinical and Concurrent Validity of the MSF-4- A Four-Item Male Sexual Function Questionnaire for Patients with Benign Prostatic Hyperplasia

Jul 1, 2001, 00:00
10.1046/j.1524-4733.2001.44021.x
https://www.valueinhealthjournal.com/article/S1098-3015(11)70043-2/fulltext
Title : Reproducibility and Clinical and Concurrent Validity of the MSF-4- A Four-Item Male Sexual Function Questionnaire for Patients with Benign Prostatic Hyperplasia
Citation : https://www.valueinhealthjournal.com/action/showCitFormats?pii=S1098-3015(11)70043-2&doi=10.1046/j.1524-4733.2001.44021.x
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Open access? : No
Section Order : 6

Introduction

The MSF-4 (Male Sexual Function 4-item) questionnaire is a condition-specific four-item scale of men's sexuality. We describe two studies that were conducted to assess the reproducibility and validity of the MSF-4 questionnaire.

Methods

Study 1 was a Phase III, multicenter study with a double-blind, parallel group design which was conducted in five countries. The objectives were to check the construct validity and factorial structure of the MSF-4, along with internal consistency reliability and clinical validity. Study 2 was a longitudinal, noncomparative, observational multicenter study to assess the reproducibility and the clinical and concurrent validity of the MSF-4.

Results

When exploratory factor analysis was performed with a free number of factors, the variability of the global MSF-4 score was based on a single factor across all countries in Study 1 except Spain. There was a high level of internal consistency reliability (Cronbach's alphas 0.68–0.90) and the MSF-4 was able to significantly discriminate different health states as assessed by the International Prostate Symptom Score (I-PSS) or Quality of Life (QoL) questionnaire. In study 2, there was a significant correlation between the MSF-4 and the International Index of Erectile Function (IIEF) scores (p = .0001 for all items) especially erectile function (correlation coefficient −0.77). The MSF-4 was able to distinguish among patients with differing degrees of benign prostatic hyperplasia (BPH) symptoms as measured by the I -PSS (p = .0001) and between those with and without sexual disorders (p = .0001).

Conclusion

The MSF-4 is a psychometrically validated questionnaire with good reproducibility and clinical validity, which allows easy and appropriate assessment of male sexual function in the clinical setting.

Categories :
  • Instrument Development, Validation, & Translation
  • Methodological & Statistical Research
  • Patient-Centered Research
  • Patient-reported Outcomes & Quality of Life Outcomes
  • Reproductive & Sexual Health
  • Specific Diseases & Conditions
  • Survey Methods
Tags :
  • Serenoa repens extract
  • 5α-reductase inhibitor
  • benign prostatic hyperplasia
  • male sexual function
  • MSF-4
  • Permixon
  • questionnaire
Regions :
  • Western Europe
ViH Article Tags :