A Systematic Review of Value Criteria for Next-Generation Sequencing/Comprehensive Genomic Profiling to Inform Value Framework Development

May 1, 2024, 00:00
10.1016/j.jval.2024.02.002
https://www.valueinhealthjournal.com/article/S1098-3015(24)00071-8/fulltext
Title : A Systematic Review of Value Criteria for Next-Generation Sequencing/Comprehensive Genomic Profiling to Inform Value Framework Development
Citation : https://www.valueinhealthjournal.com/action/showCitFormats?pii=S1098-3015(24)00071-8&doi=10.1016/j.jval.2024.02.002
First page : 670
Section Title : SYSTEMATIC LITERATURE REVIEW
Open access? : No
Section Order : 670

Objectives

To comprehensively identify and map an exhaustive list of value criteria for the assessment of next-generation sequencing/comprehensive genomic profiling (NGS/CGP), to be used as an aid in decision making.

Methods

We conducted a systematic review to identify existing value frameworks (VFs) applicable to any type of healthcare technology. VFs and criteria were mapped to a previously published Latin American (LA) VF to harmonize definitions and identify additional criteria and or subcriteria. Based on this analysis, we extracted a comprehensive, evidence-based list of criteria and subcriteria to be considered in the design of a NGS/CGP VF.

Results

A total of 42 additional VFs were compared with the LA VF, 88% were developed in high-income countries, 30% targeted genomic testing, and 16% specifically targeted oncology. A total of 242 criteria and subcriteria were extracted; 227 (94%) were fully/partially included in the LA VF; and 15 (6%) were new. Clinical benefit and economic aspects were the most common criteria. VFs oriented to genomic testing showed significant overlap with other VFs. Considering all criteria and subcriteria, a total of 18 criteria and 36 individual subcriteria were identified.

Conclusions

Our study provides an evidence-based set of criteria and subcriteria for healthcare decision making useful for NGS/CGP as well as other health technologies. The resulting list can be beneficial to inform decision making and will serve as a foundation to co-create a multistakeholder NGS/CGP VF that is aligned with the needs and values of health systems and could help to improve patient access to high-value technologies.

Categories :
  • Genetic, Regenerative & Curative Therapies
  • Health Technology Assessment
  • Literature Review & Synthesis
  • Personalized & Precision Medicine
  • Specialized Treatment Areas
  • Study Approaches
  • Value Frameworks & Dossier Format
Tags :
  • CGP
  • diagnostic
  • HTA
  • NGS
  • systematic review
  • value framework
Regions :
  • Global
ViH Article Tags :