Central Venous Access Devices for the Delivery of Systemic Anticancer Therapy: An Economic Evaluation

Jan 1, 2024, 00:00
10.1016/j.jval.2023.09.2996
https://www.valueinhealthjournal.com/article/S1098-3015(23)06148-X/fulltext
Title : Central Venous Access Devices for the Delivery of Systemic Anticancer Therapy: An Economic Evaluation
Citation : https://www.valueinhealthjournal.com/action/showCitFormats?pii=S1098-3015(23)06148-X&doi=10.1016/j.jval.2023.09.2996
First page : 7
Section Title : ECONOMIC EVALUATION
Open access? : Yes
Section Order : 7

Objectives

Patients undergoing long-term anticancer therapy typically require one of 3 venous access devices: Hickman-type device (HICK), peripherally inserted central catheter (PICC), or implantable chest wall port (PORT). Recent evidence has shown PORT is safer and improves patient satisfaction. However, PORT did not show improvement in quality-adjusted life-years and was more expensive. Decisions regarding cost-effectiveness in the United Kingdom are typically informed by a cost-per-quality-adjusted life-year metric. However, this approach is limited in its ability to capture the full range of relevant outcomes, especially in the context of medical devices. This study assessed the potential cost-effectiveness of HICK, PICC, and PORT in routine clinical practice.

Methods

This is a cost-consequence analysis to determine the trade-offs between the following outcomes: complication, infection, noninfection, chemotherapy interruption, unplanned device removals, health utilities, device insertion cost, follow-up cost, and total cost, using data from the Cancer and Venous Access clinical trial. We conducted value of implementation analysis of a PORT service.

Results

PORT was superior in terms of overall complication rate compared with both HICK (incidence rate ratio 0.422; 95% CI 0.286-0.622) and PICC (incidence rate ratio 0.295; 95% CI 0.189-0.458) and less likely to lead to an unplanned device removal. There was no difference in chemotherapy interruption or health utilities. Total cost with device in situ was lower on PORT than HICK (−£98.86; 95% CI −189.20 to −8.53) and comparable with PICC −£48.57 (95% CI −164.99 to 67.86). Value of implementation analysis found that PORT was likely to be considered cost-effective within the National Health Service.

Conclusion

Decision makers should consider including PORT within the suite of venous access devices available within in the National Health Service.

Categories :
  • Cost-comparison, Effectiveness, Utility, Benefit Analysis
  • Economic Evaluation
  • Oncology
  • Retrospective Databases: Electronic Medical and Health Records, Admin Claims
  • Specific Diseases & Conditions
  • Study Approaches
Tags :
  • cost-consequence
  • value of implementation
  • venous access device
Regions :
  • Western Europe
ViH Article Tags :