It is typical in cost-effectiveness analysis to invoke a normative decision-making framework that assumes, as a starting point, that “a quality-adjusted life-year (QALY) is a QALY is a QALY.” The implication of this assumption is that the decision maker is risk neutral and that expected values could be considered sufficiently informative for a given “approve or reject” decision. Nevertheless, it seems intuitive that less uncertainty should be desirable and this has led some to incorporate “real” risk aversion (RA) into cost-effectiveness analysis.