A Direct Comparison of the Measurement Properties of EQ-5D-5L, PROMIS-29+2 PROMIS Global Health Instruments and EQ-5D-5L and PROPr Utilities in a General Population Sample [Editor's Choice]

Jul 1, 2023, 00:00
10.1016/j.jval.2023.02.002
https://www.valueinhealthjournal.com/article/S1098-3015(23)00049-9/fulltext
Title : A Direct Comparison of the Measurement Properties of EQ-5D-5L, PROMIS-29+2 PROMIS Global Health Instruments and EQ-5D-5L and PROPr Utilities in a General Population Sample [Editor's Choice]
Citation : https://www.valueinhealthjournal.com/action/showCitFormats?pii=S1098-3015(23)00049-9&doi=10.1016/j.jval.2023.02.002
First page : 1045
Section Title : PATIENT-REPORTED OUTCOMES
Open access? : Yes
Section Order : 1045

Objectives

We aimed to compare measurement properties of the 5-level version of EQ-5D (EQ-5D-5L) and 2 Patient-Reported Outcomes Measurement Information System (PROMIS) short forms, PROMIS-29+2 and PROMIS Global Health (PROMIS-GH-10), and of EQ-5D-5L and PROMIS-preference scoring system (PROPr) utilities.

Methods

A cross-sectional survey was conducted in a general population sample in Hungary (N = 1631). We compared the following measurement properties at the level of items, domains, and utilities, the latter using corresponding US value sets: ceiling and floor, informativity (Shannon’s indices), agreement, convergent, and known-group validity. For the analyses, PROMIS items/domains were matched to EQ-5D-5L domains that cover similar concepts of health.

Results

The majority of PROMIS items showed enhanced distributional characteristics, including lower ceilings and higher informativity than the EQ-5D-5L. Good convergent validity was established between EQ-5D-5L and PROMIS domains capturing similar aspects of health. Mean EQ-5D-5L utilities were substantially higher than those of PROPr (0.864 vs 0.535). EQ-5D-5L utilities correlated moderately or strongly with PROPr (r = 0.61), PROMIS-GH-10 physical (r = 0.68), and mental health summary scores (r = 0.53). EQ-5D-5L utilities decreased with age, whereas PROPr utilities slightly increased with age. EQ-5D-5L utilities discriminated significantly better in 12/28 (ratio of F-statistics) and 18/26 (area under the receiver-operating characteristics curve ratio) known groups defined by age, self-perceived health status, and self-reported physician-diagnosed health conditions, including hypertension, diabetes, coronary heart disease, chronic kidney disease, and stroke.

Conclusions

This study provides comparative evidence on the measurement properties of EQ-5D-5L, PROMIS-29+2, and PROMIS-GH-10 and informs decisions about the choice of instruments in population health surveys for assessment of patients’ health and for cost-utility analyses.

Categories :
  • Health State Utilities
  • Patient-Centered Research
  • Patient-reported Outcomes & Quality of Life Outcomes
  • Study Approaches
  • Surveys & Expert Panels
Tags :
  • EQ-5D-5L
  • generic preference-accompanied measures
  • PROMIS
  • psychometrics
  • utilities
Regions :
  • Eastern and Central Europe
ViH Article Tags :