Potential Gains in Health-Adjusted Life Expectancy by Reducing Burden of Noncommunicable Diseases in 188 Countries: A Population-Based Study

Jun 1, 2023, 00:00 AM
10.1016/j.jval.2022.12.008
https://www.valueinhealthjournal.com/article/S1098-3015(22)04782-9/fulltext
Section Title : COMPARATIVE-EFFECTIVENESS RESEARCH/HTA
Section Order : 802
First Page : 802

Objectives

This article quantifies the potential gains in health-adjusted life expectancy for people aged 30 to 70 years (HALE ) by examining the reductions in disability in addition to premature mortality from noncommunicable diseases (NCDs).

Methods

We extracted data from the Global Burden of Disease Study 2019 for 4 major NCDs (cancers, cardiovascular diseases, chronic respiratory diseases, and diabetes mellitus) in 188 countries from 2010 to 2019. Estimates of the potential gains in HALE were based on a counterfactual analysis involving 3 alternative future scenarios: (1) achieve Sustainable Development Goals target 3.4 but do not make any progress on disability reduction, (2) achieve Sustainable Development Goals target 3.4 and eliminate NCD-related disability, and (3) eliminate all NCD-related mortality and disability.

Results

In all scenarios, the high-income group has the greatest potential gains in HALE , above the global average. For all specific causes, potential gains in HALE decrease as income levels fall. Across these 3 scenarios, the potential gains in HALE globally of reducing premature mortality for 4 major NCDs are 3.13 years, 4.53 years, and 7.32 years, respectively. In scenario A, all income groups have the greatest potential gains in HALE from diabetes and chronic respiratory diseases. In scenarios B and C, the high-income group has the greatest potential gains in HALE from cancer intervention, and the other income groups have the greatest potential gains in HALE from cardiovascular diseases intervention.

Conclusion

Reducing premature death and disability from 4 major NCDs at once and attaching equal importance to each lead to a sizable improvement in HALE .

https://www.valueinhealthjournal.com/action/showCitFormats?pii=S1098-3015(22)04782-9&doi=10.1016/j.jval.2022.12.008
HEOR Topics :
  • Epidemiology & Public Health
  • Infectious Disease
  • Safety & Pharmacoepidemiology
  • Specific Diseases & Conditions
Tags :
  • Bayesian age-period-cohort model
  • global health
  • health-adjusted life expectancy
  • noncommunicable diseases
  • sustainable development goals
Regions :
  • Global