Current Health State Affected Patient Preferences More Than Disease Status: A Discrete Choice Experiment in Multiple Myeloma

Jun 1, 2023, 00:00
10.1016/j.jval.2023.01.016
https://www.valueinhealthjournal.com/article/S1098-3015(23)00041-4/fulltext
Title : Current Health State Affected Patient Preferences More Than Disease Status: A Discrete Choice Experiment in Multiple Myeloma
Citation : https://www.valueinhealthjournal.com/action/showCitFormats?pii=S1098-3015(23)00041-4&doi=10.1016/j.jval.2023.01.016
First page : 909
Section Title : PREFERENCE-BASED ASSESSMENTS
Open access? : Yes
Section Order : 909

Objectives

To examine how disease status and current health state influence treatment preferences of patients with multiple myeloma (MM).

Methods

Participants with MM from France, Germany, and the United Kingdom completed a web-based survey that included a discrete choice experiment (DCE) and EQ-5D assessment. The DCE elicited preferences for 8 attributes: increased life expectancy, increased time to relapse, pain, fatigue, risk of infection, administration (route and duration), frequency of administration, and monitoring. Multinomial logit models were used to analyze DCE preference data and to calculate life expectancy trade-offs.

Results

Three hundred participants with MM (newly diagnosed, transplant eligible, n = 108; newly diagnosed, transplant ineligible, n = 105; relapsed-refractory, n = 87) completed the survey. The most valued attributes were pain, fatigue, and increased life expectancy. Participants would want an additional 2.7 years of life expectancy (95% confidence interval [CI] 2.4-3.1 years) to tolerate extreme pain and an additional 2.0 years of life expectancy (95% CI 1.6-2.3 years) to tolerate constant fatigue. Participants in a better health state (third EQ-5D score quartile [0.897]) required less additional life expectancy than participants with a worse health state (first EQ-5D score quartile [0.662]) to tolerate extreme pain (2.3 years [95% CI 1.9-2.6 years] vs 3.0 years [95% CI 2.6-3.4 years]; P = .007). There was little difference in treatment preferences between newly diagnosed and relapsed-refractory patients for pain, fatigue, and increased life expectancy.

Conclusions

Current health state influenced treatment preferences of patients with MM more than disease status and should be considered when making treatment decisions.

Categories :
  • Decision & Deliberative Processes
  • Health State Utilities
  • Health Technology Assessment
  • Methodological & Statistical Research
  • Oncology
  • Patient-Centered Research
  • Preference Methods
  • Specific Diseases & Conditions
  • Study Approaches
  • Surveys & Expert Panels
Tags :
  • discrete choice experiment
  • disease status
  • health state
  • multiple myeloma
  • patient preference
Regions :
  • Western Europe
ViH Article Tags :