Cost-Effectiveness Analysis of a National Pre-Exposure Prophylaxis (PrEP) Program in Ireland

Jul 1, 2021, 00:00
10.1016/j.jval.2021.02.005
https://www.valueinhealthjournal.com/article/S1098-3015(21)00144-3/fulltext
Title : Cost-Effectiveness Analysis of a National Pre-Exposure Prophylaxis (PrEP) Program in Ireland
Citation : https://www.valueinhealthjournal.com/action/showCitFormats?pii=S1098-3015(21)00144-3&doi=10.1016/j.jval.2021.02.005
First page : 948
Section Title : ECONOMIC EVALUATION
Open access? : No
Section Order : 948

Objectives

To estimate the cost-effectiveness of introducing a publicly funded pre-exposure prophylaxis (PrEP) program in Ireland.

Methods

We constructed a state-transition Markov model. This was a cross-sectional population model that tracked all HIV-negative men who have sex with men (MSM) in Ireland over their lifetime. Access to a publicly funded PrEP program (medications + frequent monitoring) in high-risk MSM was compared with no PrEP. The primary outcome measure was the incremental cost-effectiveness ratio (ICER).

Results

In the base case, introducing a PrEP program was considered cost saving and provided significant health benefits to the population. Univariate sensitivity analysis demonstrated that PrEP efficacy and HIV incidence had the greatest impact on cost-effectiveness. Including an increase in sexually transmitted infections had a negligible impact on the results.

Conclusion

We found that the introduction of a PrEP program would be considered cost saving in the first cost-effectiveness analysis of its kind in Ireland.

Categories :
  • Clinical Trials
  • Cost/Cost of Illness/Resource Use Studies
  • Cost-comparison, Effectiveness, Utility, Benefit Analysis
  • Economic Evaluation
  • Infectious Disease
  • Reproductive & Sexual Health
  • Specific Diseases & Conditions
  • Study Approaches
Tags :
  • cost-effectiveness analysis
  • HIV prevention
  • pre-exposure prophylaxis
  • PrEP
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