Social Impact of Prophylactic Migraine Treatments in Germany: A State-Transition and Open Cohort Approach

Oct 1, 2021, 00:00
10.1016/j.jval.2021.04.1281
https://www.valueinhealthjournal.com/article/S1098-3015(21)01535-7/fulltext
Title : Social Impact of Prophylactic Migraine Treatments in Germany: A State-Transition and Open Cohort Approach
Citation : https://www.valueinhealthjournal.com/action/showCitFormats?pii=S1098-3015(21)01535-7&doi=10.1016/j.jval.2021.04.1281
First page : 1446
Section Title : ECONOMIC EVALUATION
Open access? : Yes
Section Order : 1446

Objectives

Migraine is a highly prevalent neurological disorder. The most characteristic symptom of migraine is moderate to severe recurrent headache along with other neurological symptoms. In this study, we modeled the potential reduction in migraine days and corresponding avoided productivity losses if erenumab was prescribed to the patient population indicated for prophylactic migraine treatment (≥ 4 monthly migraine days [MMDs]) in Germany from 2020 to the end of 2027.

Methods

We simulated the incremental benefits of erenumab against the standard of care. Response rates, transition probabilities, discontinuation rates, and productivity estimates were derived from the erenumab clinical trial program. Patients had a probability of residing in 1 of 7 states, given the MMDs in addition to the probability of death. Based on accrued MMDs in every cycle, days of absenteeism and presenteeism for paid and unpaid work were derived. Paid work was monetized according to gross value added using the human capital approach, whereas unpaid work was valuated according to the proxy good method. In addition, downstream macroeconomic effects were captured using value-added multipliers. Direct medical costs were concomitantly calculated.

Results

Our results show that prescribing erenumab for the indicated population in Germany could lead to a reduction of 166 million migraine days annually and reduce productivity losses in the range of €27 billion. This includes €13.1 billion from direct productivity and €13.5 billion from economic value chain effects.

Conclusions

This study highlights the macroeconomic effects of a systematic introduction of novel inhibitors of the calcitonin gene-related peptide pathway for migraine in Germany.

Categories :
  • Cost-comparison, Effectiveness, Utility, Benefit Analysis
  • Economic Evaluation
  • Methodological & Statistical Research
  • Modeling and simulation
  • Specific Diseases & Conditions
  • Work & Home Productivity - Indirect Costs
Tags :
  • Aimovig
  • erenumab
  • migraine disorders
  • population model
  • societal cost
  • unpaid work
  • work productivity
Regions :
  • Western Europe
ViH Article Tags :