Health State Utility Values in Schizophrenia: A Systematic Review and Meta-Analysis

Sep 1, 2020, 00:00
10.1016/j.jval.2020.05.014
https://www.valueinhealthjournal.com/article/S1098-3015(20)32126-4/fulltext
Title : Health State Utility Values in Schizophrenia: A Systematic Review and Meta-Analysis
Citation : https://www.valueinhealthjournal.com/action/showCitFormats?pii=S1098-3015(20)32126-4&doi=10.1016/j.jval.2020.05.014
First page : 1256
Section Title : SYSTEMATIC LITERATURE REVIEW
Open access? : No
Section Order : 1256

Objectives

Patient preferences are increasingly important in informing clinical and policy decisions. Health-state utility values (HSUVs) are quantitative measures of people’s preferences over different health states. In schizophrenia, there is no clarity about HSUVs across the symptoms’ severity spectrum. This meta-analysis aims to synthesize the literature on HSUVs in people with schizophrenia.

Methods

We searched Medline, PsycInfo, Embase, EconLit, The Cochrane Library, and specialized databases. The studies reporting HSUVs in people with schizophrenia were selected and pooled in a random-effects meta-analysis. The primary outcome was the mean HSUV obtained from participants.

Results

A total of 54 studies involving 87 335 participants were included. The pooled estimate using direct elicitation was a mean HSUV of 0.79 (95% CI: 0.70-0.88) for mild symptomatic states, 0.69 (95% CI: 0.54-0.85) in moderate states, and 0.34 (95% CI: 0.13-0.56) in severe states. Studies using indirect techniques resulted in a pooled mean HSUV of 0.73 (95% CI: 0.67-0.78) applying the EuroQol 5-dimension, 0.66 (95% CI: 0.62-0.71) in the Short-Form 6-dimension, and 0.59 (95% CI: 0.57-0.61) using the Quality of Well-Being scale. All the estimates resulted in considerable heterogeneity, partially reduced by meta-regression.

Conclusion

Our findings suggest that the severity of psychotic symptoms has an important effect on HSUVs in schizophrenia, with values mirroring patients with disabling physical conditions such as cancer and stroke. Decision makers should be aware of these results when including people’s preferences in trials, models and policy decisions.

Categories :
  • Economic Evaluation
  • Health State Utilities
  • Literature Review & Synthesis
  • Mental Health
  • Patient-Centered Research
  • Specific Diseases & Conditions
  • Study Approaches
Tags :
  • economic evaluation
  • health-state utility values
  • meta-analysis
  • schizophrenia
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