Author's Reply:

We thank the editor for giving us the opportunity to respond to the letter to the editor regarding our recent publication on multiple medication adherence (MMA).¹ We also thank the authors of the letter to the editor for their interest in our paper and for providing their comments, as it validates the timeliness and importance of this topic and offers the opportunity for an ardent discussion, which we believe is a hallmark of good science. At issue, in this case, is the measurement of adherence that involves polytherapeutic regimens. Although it is a methodologically challenging endeavor, subject to multiple dimensions and varied opinions, we believe that as more patients experience numerous medical comorbidities and hence polypharmacy needs, additional insights and novel approaches will be required to better document adherence measures. One of our intentions in documenting currently utilized MMA methods in our systematic review was to support future insights and novel approaches that we believe will ultimately support the viewpoint that ability of adherence to predict and stimulate action should be the focus.