Evaluation of Resource Utilization and Treatment Patterns in Patients with Actinic Keratosis in the United States

Mar 1, 2016, 00:00
10.1016/j.jval.2015.11.014
https://www.valueinhealthjournal.com/article/S1098-3015(15)05137-2/fulltext
Title : Evaluation of Resource Utilization and Treatment Patterns in Patients with Actinic Keratosis in the United States
Citation : https://www.valueinhealthjournal.com/action/showCitFormats?pii=S1098-3015(15)05137-2&doi=10.1016/j.jval.2015.11.014
First page : 239
Section Title : Comparative Effectiveness Research/HTA
Open access? : No
Section Order : 15

Objective

To compare health care resource utilization and treatment patterns between patients with actinic keratosis (AK) treated with ingenol mebutate gel (IngMeb) and those treated with other field-directed AK therapies.

Methods

A retrospective, propensity-score–matched, cohort study compared refill/repeat and adding-on/switching patterns and outpatient visits and prescriptions (health care resource utilization) over 6 months in patients receiving IngMeb versus those receiving imiquimod, 5-fluorouracil, diclofenac sodium, and methyl aminolevulinate or aminolevulinic acid photodynamic therapy (MAL/ALA-PDT).

Results

The final sample analyzed included four matched treatment cohort pairs (IngMeb and comparator; n = 790–971 per treatment arm). Refill rates were similar except for imiquimod (15% vs. 9% for imiquimod and IngMeb, respectively; P 0.0001). There were significantly fewer AK-related prescriptions among patients receiving IngMeb than among patients in other cohorts.

Conclusions

Results based on the first 6 months after treatment initiation suggested that most field-directed AK therapies had clinically comparable treatment patterns except imiquimod, which was associated with higher refill rates, and PDT, which was associated with significantly more frequent treatment sessions and higher switching rates. IngMeb was also associated with significantly fewer outpatient visits than were other field-directed therapies.

Categories :
  • Cost/Cost of Illness/Resource Use Studies
  • Economic Evaluation
  • Health Service Delivery & Process of Care
  • Sensory System Disorders
  • Specific Diseases & Conditions
  • Treatment Patterns and Guidelines
Tags :
  • actinic keratosis
  • health care resource utilization
  • treatment patterns
Regions :
  • North America
ViH Article Tags :