Economic Assessment of an Anti-HCV Screening Program in Italy

Sep 1, 2013, 00:00
10.1016/j.jval.2013.07.005
https://www.valueinhealthjournal.com/article/S1098-3015(13)01903-7/fulltext
Title : Economic Assessment of an Anti-HCV Screening Program in Italy
Citation : https://www.valueinhealthjournal.com/action/showCitFormats?pii=S1098-3015(13)01903-7&doi=10.1016/j.jval.2013.07.005
First page : 965
Section Title : Economic Evaluation
Open access? : No
Section Order : 18

Background

The progression of hepatitis C virus (HCV) disease usually occurs over a 10-year period. HCV-related complications as well as the highly debilitating effects on patients represent a significant item of expenditure for the National Health Service. Early detection of HCV infection is an excellent opportunity to improve patients’ quality of life and to rationalize resource allocation.

Objective

The aim of this study was to provide a cost-effectiveness evaluation of an anti-HCV screening program in the Italian National Health Service perspective.

Methods

We built a Markov model made up of two arms. The ‘‘Test Strategy’’ arm involves a screening program based on the enzyme immunoassay for detection of antibodies as first-level test and the research of HCV RNA as second-level detection; patients with positive test results are treated with peg-interferon alfa in combination with ribavirine. Parameters were derived from the literature and validated through experts’ opinion. Costs and benefits were discounted by 3.5%. Results were expressed as cost/quality-adjusted life-year (QALY) gained through the screening program compared with the treatment of symptomatic patients. Deterministic and probabilistic sensitivity analysis was performed.

Results

The incremental cost-effectiveness ratio of the ‘‘Test Strategy’’ is €5171/QALY, definitively below the cost/QALY of other approved treatments in Italy. Model results turned out as sensitive to the age of the target population, the prevalence of HCV infection, and the time horizon adopted.

Conclusions

The anti-HCV screening program is a valid health-related investment improving patients’ quality of life and survival with an acceptable expenditure increase for the National Health Service.

Categories :
  • Cost-comparison, Effectiveness, Utility, Benefit Analysis
  • Economic Evaluation
  • Infectious Disease
  • Specific Diseases & Conditions
Tags :
  • cost-effectiveness
  • Italy
  • liver disease
  • Markov model
Regions :
  • Africa
  • Eastern and Central Europe
  • Middle East
ViH Article Tags :