Impact of Interventions on Medication Adherence and Blood Pressure Control in Patients with Essential Hypertension- A Systematic Review by the ISPOR Medication Adherence and Persistence Special Interest Group

Jul 1, 2013, 00:00
10.1016/j.jval.2013.03.1631
https://www.valueinhealthjournal.com/article/S1098-3015(13)01800-7/fulltext
Title : Impact of Interventions on Medication Adherence and Blood Pressure Control in Patients with Essential Hypertension- A Systematic Review by the ISPOR Medication Adherence and Persistence Special Interest Group
Citation : https://www.valueinhealthjournal.com/action/showCitFormats?pii=S1098-3015(13)01800-7&doi=10.1016/j.jval.2013.03.1631
First page : 863
Section Title : Systematic Reviews
Open access? : No
Section Order : 20

Objectives

To systematically review the evidence on the impact of interventions to improve medication adherence in adults prescribed antihypertensive medications.

Methods

An electronic search was undertaken of articles published between 1979 and 2009, without language restriction, that focused on interventions to improve antihypertensive medication adherence among patients (≥18 years) with essential hypertension. Studies must have measured adherence as an outcome of the intervention. We followed standard guidelines for the conduct and reporting of the review and conducted a narrative synthesis of reported data.

Results

Ninety-seven articles were identified for inclusion; 35 (35 of 97, 36.1%) examined interventions to directly improve medication adherence, and the majority (58 of 97, 59.8%) were randomized controlled trials. Thirty-four (34 of 97, 35.1%) studies reported a statistically significant improvement in medication adherence.

Discussion/Conclusions

Interventions aimed at improving patients’ knowledge of medications possess the greatest potential clinical value in improving adherence with antihypertensive therapy. However, we identified several limitations of these studies, and advise future researchers to focus on using validated adherence measures, well-designed randomized controlled trials with relevant adherence and clinical outcomes, and guidelines on the appropriate design and analysis of adherence research.

Categories :
  • Cardiovascular Disorders
  • Epidemiology & Public Health
  • Literature Review & Synthesis
  • Safety & Pharmacoepidemiology
  • Specific Diseases & Conditions
  • Study Approaches
Tags :
  • hypertension
  • intervention
  • medication adherence
  • uncontrolled blood pressure
Regions :
  • Global
ViH Article Tags :