Estimation of a Multiattribute Utility Function for the Spanish Version of the TooL Questionnaire

Jun 1, 2011, 00:00
10.1016/j.jval.2010.11.016
https://www.valueinhealthjournal.com/article/S1098-3015(10)00087-2/fulltext
Title : Estimation of a Multiattribute Utility Function for the Spanish Version of the TooL Questionnaire
Citation : https://www.valueinhealthjournal.com/action/showCitFormats?pii=S1098-3015(10)00087-2&doi=10.1016/j.jval.2010.11.016
First page : 564
Section Title : Preference-Based Assessment
Open access? : No
Section Order : 20

Objectives

To estimate and assess the psychometric properties of a multiattribute utility function (MAUF) for the Spanish version of the Tolerability and Quality of Life (TooL questionnaire).

Methods

Balanced data on 243 patients diagnosed with schizophrenia or bipolar disorder were gathered. In addition to the demographic and clinical variables and the usual generic health-related quality of life (HRQoL) questionnaires (EuroQol-5D [EQ-5D] and Short Form-6D [SF-6D]), instruments considered included the Spanish versions of the Positive and Negative Symptoms of Schizophrenia Scale (PANSS), Young Mania Rating Scale (YMRS), Montgomery-Asberg Depression Rating Scale (MADRS), Udvalg for Kliniske Undersogelser (UKU), and Clinical Global Impression Severity (CGIS) scale. MAUF parameters estimation involved a number of visual analogue scale (VAS) and time trade-off (TTO) ratings that proved difficult to be performed by the patients. After checking for inconsistencies in patient responses, the original sample was reduced to a still balanced subsample of 70 individuals. A multiplicative-form MAUF was estimated following the standard methodology.

Results

Good convergent validity was demonstrated because utility estimates from the MAUF presented strong correlations with utilities from the generic HRQoL instruments included: SF-6D (0.66, P 0.01). Utilities from the MAUF covered a wider range of health states [0.04,1.00] than those from the SF-6D [0.53,1.00] and EQ-5D [0.23,0.96].

Conclusions

Utilities from the MAUF showed good psychometric properties, serving as a complement to generic health utilities. If misapplied, however, utilities from this instrument might favor the positive evaluation of drugs showing fewer associated side effects.

Categories :
  • Health State Utilities
  • Mental Health
  • Patient-Centered Research
  • Patient-reported Outcomes & Quality of Life Outcomes
  • Specific Diseases & Conditions
Tags :
  • bipolar disorder
  • multiattribute utility function
  • schizophrenia
  • specific health-related utilities
Regions :
  • Eastern and Central Europe
ViH Article Tags :